目的 探討金天格膠囊聯(lián)合美洛昔康治療膝骨關(guān)節(jié)炎的臨床療效。方法 選取2016年4月-2017年7月在內(nèi)蒙古醫(yī)科大學(xué)附屬醫(yī)院就診的膝骨關(guān)節(jié)炎患者83例，隨機(jī)分為對(duì)照組（42例）和治療組（41例）。對(duì)照組口服美洛昔康片，2片/次，3次/d。治療組在對(duì)照組治療基礎(chǔ)上口服金天格膠囊，3粒/次，3次/d。兩組患者均連續(xù)治療12周。觀察兩組的臨床療效，比較兩組治療前后Lysholm評(píng)分、膝關(guān)節(jié)屈曲度、VAS評(píng)分的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為73.81%、82.93%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者疼痛感評(píng)分、內(nèi)外翻畸形評(píng)分、關(guān)節(jié)活動(dòng)度評(píng)分、主動(dòng)延伸受限評(píng)分、行走能力評(píng)分、日?；顒?dòng)評(píng)分、總分、膝關(guān)節(jié)屈曲度均明顯增加，VAS評(píng)分顯著降低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組疼痛感評(píng)分、內(nèi)外翻畸形評(píng)分、關(guān)節(jié)活動(dòng)度評(píng)分、主動(dòng)延伸受限評(píng)分、行走能力評(píng)分、日?；顒?dòng)評(píng)分、總分、膝關(guān)節(jié)屈曲度顯著高于對(duì)照組，VAS評(píng)分低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 金天格膠囊聯(lián)合美洛昔康治療膝骨關(guān)節(jié)炎具有較好的臨床療效，可提高膝關(guān)節(jié)功能的康復(fù)效果，降低患者疼痛，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Jintiange Capsules combined with meloxicam in treatment of knee osteoarthritis. Methods Patients (83 cases) with knee osteoarthritis in Affiliated Hospital of Inner Mongolia Medical University from April 2016 to July 2017 were randomly divided into control (42 cases) and treatment (41 cases) groups. Patients in the control group were po administered with Meloxicam Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Jintiange Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the changes of Lysholm scores, knee flexion degree and VAS scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 73.81% and 82.93%, respectively, and there were differences between two groups (P<0.05). After treatment, pain sensitivity score, internal and external deformity score, joint activity score, active extension restricted score, walking ability score, daily activity score, total score, and knee flexion degree in two groups were increased, but VAS score was decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, pain sensitivity score, internal and external deformity score, joint activity score, active extension restricted score, walking ability score, daily activity score, total score, and knee flexion degree in the treatment group were higher than those in the control group, but VAS score was lower than that in the control group, and there was difference between two groups (P<0.05). Conclusion Jintiange Capsules combined with meloxicam has clinical curative effect in treatment of knee osteoarthritis, and can improve the function of the knee, also can reduce the pain, which has a certain clinical application value.

內(nèi)蒙古自治區(qū)自然科學(xué)基金資助項(xiàng)目（2016MS0827）