目的 探討萆薢分清丸聯(lián)合頭孢唑肟鈉治療尿路感染的臨床療效。方法 選取2015年11月-2017年1月在上海市寶山區(qū)中西醫(yī)結(jié)合醫(yī)院進(jìn)行治療的尿路感染患者200例，隨機(jī)分為對(duì)照組（100例）和治療組（100例）。對(duì)照組患者靜脈滴注注射用頭孢唑肟鈉，2 g/次，2次/d。治療組在對(duì)照組的基礎(chǔ)上口服萆薢分清丸，6 g/次，2次/d。兩組患者均連續(xù)治療7 d。觀察兩組患者臨床效果，比較兩組患者治療前后臨床癥狀改善時(shí)間和血清細(xì)胞因子水平。結(jié)果 治療后，對(duì)照組和治療組臨床有效率分別為83.00%和97.00%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組患者尿頻、尿急和尿痛改善時(shí)間比對(duì)照組顯著縮短，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清降鈣素原（PCT）、C反應(yīng)蛋白（CRP）和白細(xì)胞介素-6（IL-6）水平均顯著降低，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者的細(xì)胞因子水平明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 萆薢分清丸聯(lián)合頭孢唑肟鈉可有效改善尿路感染患者臨床癥狀，降低機(jī)體PCT水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To evaluate the clinical efficacy of Bixie Fenqing Pills combined with ceftizoxime sodium in treatment of urinary tract infection. Methods Patients (200 cases) with urinary tract infection in Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine in Shanghai from November 2015 to January 2017 were randomly divided into control (100 cases) and treatment (100 cases) groups. Patients in the control group were iv administered with Ceftizoxime Sodium for injection, 2 g/time, twice daily. Patients in the treatment group were po administered with Bixie Fenqing Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and clinical symptom improvement time and serum cytokine levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.00% and 97.00%, respectively, and there were differences between two groups (P<0.05). After treatment, the improvement time of frequent micturition, urgency to urinate and odynuria in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the PCT, CRP and IL-6 levels in two groups were significantly decreased, and there were differences in the same group (P<0.05). And the serum cytokine levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Bixie Fenqing Pills combined with ceftizoxime sodium can effectively improve the clinical symptoms in treatment of urinary tract infection, and reduce the PCT, CRP and IL-6 levels, which has a certain clinical application value.