目的 探討血必凈聯(lián)合重組牛堿性成纖維細(xì)胞生長(zhǎng)因子凝膠治療深度燒傷殘余創(chuàng)面的臨床療效。方法 收集2015年2月-2017年2月在安陽(yáng)市人民醫(yī)院進(jìn)行治療的深度燒傷患者78例，根據(jù)用藥的差別分為對(duì)照組（39例）和治療組（39例）。對(duì)照組于患處涂抹重組牛堿性成纖維細(xì)胞生長(zhǎng)因子凝膠，每次300 IU/cm²，2次/d。治療組在對(duì)照組的基礎(chǔ)上靜脈滴注血必凈注射液，100 mL加入生理鹽水100 mL，1次/d。兩組患者均經(jīng)過2周治療。觀察兩組患者臨床療效，比較治療前后兩組患者細(xì)菌清除率、血清學(xué)指標(biāo)和創(chuàng)面愈合時(shí)間。結(jié)果 治療后，對(duì)照組和治療組的臨床總有效率分別為79.49%、94.87%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對(duì)照組的細(xì)菌清除率為54.84%，明顯低于治療組的84.38%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清IL-1β、IL-6和腫瘤壞死因子-α（TNF-α）水平均顯著降低，IL-4和IL-10水平均增高，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組血清學(xué)指標(biāo)比對(duì)照組改善更明顯，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療組創(chuàng)面愈合時(shí)間明顯短于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 血必凈聯(lián)合重組牛堿性成纖維細(xì)胞生長(zhǎng)因子凝膠治療深度燒傷殘余創(chuàng)面可有效降低機(jī)體炎癥反應(yīng)，促進(jìn)創(chuàng)面愈合，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the efficacy of Xuebijing Injection combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel in treatment of residue wound surface of deep burn. Methods Patients (78 cases) with residue wound surface of deep burn in Anyang People's Hospital from February 2015 to February 2017 were divided into control (39 cases) and treatment (39 cases) groups according to different treatments. Patients in the control group applied Recombinant Bovine Basic Fibroblast Growth Factor Gel on the residue wound surface, 300 IU/cm² for each time, twice daily. Patients in the treatment group were iv administered with Xuebijing Injection on the basis of the control group, 100 mL added into normal saline 100 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the bacterial clearance rate, serological indexes and the time of wound healing in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 79.49% and 94.87%, respectively, and there were differences between two groups (P<0.05). After treatment, the bacterial clearance rate in the control group was 54.84%, which were significantly lower than 84.38% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the IL-1β, IL-6 and TNF-α levels in two groups were significantly decreased, but IL-4 and IL-10 levels were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the serological indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). The time of wound healing in the treatment was significantly earlier than that in the control group, with significant difference between two groups (P<0.05). Conclusion Xuebijing Injection combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel can effectively reduce the inflammatory reaction and promote wound healing in treatment of residue wound surface of deep burn, which has a certain clinical application value.