目的 探討卡泊三醇軟膏聯(lián)合鈣泊三醇倍他米松軟膏治療慢性濕疹的臨床療效。方法 選取2015年1月-2017年1月徐州市中心醫(yī)院收治的慢性濕疹患者102例為研究對象，按照數(shù)表法將患者隨機分為對照組（50例）和治療組（52例）。對照組患處涂抹鈣泊三醇倍他米松軟膏，10 g/次，1次/d，1周用量不超過100 g。治療組在對照組的基礎(chǔ)上涂抹卡泊三醇軟膏，5 g/次，2次/d，1周用量不超過100 g。兩組患者均連續(xù)治療8周。觀察兩組的臨床療效，比較兩組的臨床體征評分、皮膚生理功能、復發(fā)和不良反應情況。結(jié)果 治療后，對照組和治療組的總有效率分別為86.0%、96.2%，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療后，兩組紅斑、浸潤和肥厚、抓痕、苔蘚化、濕疹面積及嚴重程度指數(shù)（EASI）評分明顯降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組經(jīng)表皮水分流失（TEWL）明顯降低，角質(zhì)層含水量（WCSC）、皮膚油脂（SC）明顯升高，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療組復發(fā)率和內(nèi)分泌紊亂、局部疼痛、局部萎縮的發(fā)生率明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結(jié)論 卡泊三醇軟膏聯(lián)合鈣泊三醇倍他米松軟膏治療慢性濕疹具有較好的臨床療效，可改善臨床癥狀，調(diào)節(jié)皮膚生理功能，降低疾病復發(fā)率，且安全性較好，具有一定的臨床推廣應用價值。

Objective To study the effect of Calcipotriol Ointment combined with Calcipotriol Betamethasone Ointment in treatment of chronic eczema. Methods Patients (102 cases) with chronic eczema in Xuzhou Central Hospital from January 2015 to January 2017 were randomly divided into control group (50 cases) and treatment group (52 cases). Patients in the control group were smear on the lesion with Calcipotriol Betamethasone Ointment, 10 g/time, once daily, and the dosage of 1 week was not more than 100 g. Patients in the treatment group were smear on the lesion with Calcipotriol Ointment on the basis of the control group, 5 g/time, twice daily, and the dosage of 1 week was not more than 100 g. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom score, skin physiological function, recurrence, and adverse reaction in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 86.0% and 96.2%, respectively, and there was difference between two groups (P < 0.05). After treatment, the scores of erythema, infiltration, hypertrophy, scratches, moss, eczema area, and EASI in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly loeer than those in the control group, with significant difference between two groups (P<0.05). After treatment, the TEWL in two groups were significantly decreased, but the WCSC and SC in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). The recurrence rate, endocrine disorders, local pain and local atrophy in the treatment group were significantly lower than those in the control group, and the differences were statistically significant between two groups (P<0.05). Conclusion Calcipotriol Ointment combined with Calcipotriol Betamethasone Ointment has clinical curative effect in treatment of chronic eczema, can improve clinical symptoms, regulate skin physiological function, and decrease the recurrence rate of the disease, with good safety, which has a certain clinical application value.