目的 探討小金片聯(lián)合甲潑尼龍片治療亞急性甲狀腺炎的臨床療效。方法 選取2015年4月-2017年4月在廣州市番禺區(qū)中醫(yī)院進行診治的亞急性甲狀腺炎患者312例，根據(jù)用藥的差別分為對照組（156例）和治療組（156例）。對照組口服甲潑尼龍片，初始劑量24 mg/d，2周后16 mg/d，4周后8 mg/d，6周后4 mg/d。治療組在對照組的基礎上口服小金片，0.72 g/次，2次/d。兩組患者均治療8周。觀察兩組患者臨床療效，比較治療前后兩組患者臨床癥狀和血清學指標改善情況。結果 治療后，對照組的臨床有效率為82.05%，顯著低于治療組的92.31%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，治療組咽痛、甲狀腺疼痛和甲狀腺腫塊消失時間以及退熱時間均明顯短于對照組患者，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患者血清C反應蛋白（CRP）、血沉、甲狀腺球蛋白抗體（TGAb）、甲狀腺微粒體抗體（TPOAb）和促甲狀腺激素受體抗體（TRAb）水平均顯著降低，同組治療前后比較差異具有統(tǒng)計學意義（P<0.05）；且治療后治療組患者上述血清學指標明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 小金片聯(lián)合甲潑尼龍片治療亞急性甲狀腺炎可有效改善患者臨床癥狀和炎癥狀態(tài)，有利于恢復受損的甲狀腺功能，具有一定的臨床推廣應用價值。

Objective To investigate the clinical efficacy of Xiaojin Tablets combined with methylprednisolone in treatment of subacute thyroiditis. Methods Patients (312 cases) with subacute thyroiditis in Guangzhou Panyu District Hospital of Traditional Chinese Medicine from April 2015 to April 2017 were divided into control (156 cases) and treatment (156 cases) groups according to different treatments. Patients in the control group were po administered with Methylprednisolone Tablets, the initial dose was 24 mg/d, and 16 mg/d after 2 weeks, 8 mg/d after 4 weeks, 4 mg/d after 6 weeks. Patients in the treatment group were po administered with Xiaojin Tablets on the basis of the control group, 0.72 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms and serological indexes in two groups before and after treatment was compared. Results After treatment, clinical efficacy in the control group was 82.05%, which were significantly lower than 92.31% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the disappearance time of pharyngodynia, thyroid pain, thyroid nodule and fever in the treatment group were significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the CRP, ESR, TGAb, TPOAb and TRAb levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serological indexes after treatment in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xiaojin Tablets combined with methylprednisolone can effectively improve the clinical symptoms and inflammatory state in treatment of subacute thyroiditis, which is conducive to the recovery of impaired thyroid function and has a certain clinical application value.