聚乙二醇（PEG）修飾是解決蛋白質藥物溶解度低、穩(wěn)定性差、半衰期短、具有免疫原性等問題的有效方法，通常在氨基上進行修飾，但在巰基上進行定點修飾更有利于獲得結構明確、組成穩(wěn)定的修飾產物。綜述了聚乙二醇定點修飾蛋白質藥物中巰基，包括在游離巰基、二硫鍵和引入的巰基上進行修飾的研究進展。

Pegylation (PEG) is an effective way to overcome problems of protein drugs, such as low solubility, bad stability, short half-life, and having immunogenicity. Usually the modification is executed on amino, while the reaction based on thiol is more likely to obtain a product with clear structure and stable composition. Research progress on site-specific PEGylation on thiol in protein drugs, which included modifications on free thiol, double-sulfide bond, and imported thiol are reviewed in this paper.

天津市科技計劃項目（15PTSYJC00220）