目的 探討芪藶強(qiáng)心膠囊聯(lián)合奧普力農(nóng)注射液治療慢性充血性心力衰竭的臨床效果。方法 選取2015年7月—2017年6月在濮陽市安陽地區(qū)醫(yī)院就診的慢性充血性心力衰竭患者148例，隨機(jī)分為對(duì)照組（74例）與治療組（74例）。對(duì)照組靜脈滴注鹽酸奧普力農(nóng)注射液，首先以10 μg/kg滴注10 min，再以0.2 μg/kg靜脈泵注250 min。治療組在對(duì)照組基礎(chǔ)上口服芪藶強(qiáng)心膠囊，4粒/次，3次/d。兩組患者連續(xù)治療1周。觀察兩組患者臨床療效，比較治療前后兩組患者心功能、脂聯(lián)素（APN）、抗利尿激素（ADH）和氨基末端腦鈉肽前體（NT-pro BNP）水平以及6 min步行試驗(yàn)（6 MWT）變化。結(jié)果 治療后，對(duì)照組和治療組臨床總有效率分別為82.43%和93.24%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者左心室收縮末期容積（LVESV）均明顯降低，心輸出量（CO）、心臟指數(shù)（CI）和左心室射血分?jǐn)?shù)（LVEF）明顯增加，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組LVESV、CO、CI和LVEF改善后水平明顯優(yōu)于對(duì)照組（P<0.05）。治療后，兩組患者血清APN、ADH和NT-pro BNP水平均顯著下降（P<0.05）；且治療組患者血清APN、ADH和NT-pro BNP水平降低的更顯著（P<0.05）。治療后，兩組患者6 MWT均比治療前顯著增加（P<0.05）；且治療組6 MWT大于對(duì)照組（P<0.05）。結(jié)論 芪藶強(qiáng)心膠囊聯(lián)合奧普力農(nóng)注射液治療慢性充血性心力衰竭可顯著提高患者的心功能，降低血清NT-pro BNP、APN和ADH水平，療效確切。

Objective To evaluate the clinical effect of Qili Qiangxin Capsules combined with olprinone in treatment of chronic congestive heart failure. Methods Patients (148 cases) with chronic congestive heart failure in Puyang Anyang District Hospital from July 2015 to June 2017 were randomly divided into control (74 cases) and treatment (74 cases) groups. Patients in the control group were iv administered with Olprinone Hydrochloride Injection, firstly dripped at the speed of 10 μg/kg for 10 min, then intravenous pumped at the speed of 0.2 μg/kg for 250 min. Patients in the treatment group were po administered with Qili Qiangxin Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the changes of cardiac function, APN, ADH and NT-pro BNP levels, and 6 MWT in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 82.43% and 93.24%, respectively, and there were differences between two groups (P < 0.05). After treatment, LVESV levels in two groups were significantly decreased, but CO, CI and LVEF levels were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the LVESV, CO, CI and LVEF levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, APN, ADH and NT-pro BNP levels in two groups were significantly decreased (P < 0.05). And the APN, ADH and NT-pro BNP levels in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the 6 MWT in two groups was significantly increased (P < 0.05). And the increase distance of 6 MWT in the treatment group was significantly longer than that in the control group (P < 0.05).Conclusion Qili Qiangxin Capsules combined with olprinone can significantly improve the cardiac function in treatment of chronic congestive heart failure, and reduce the serum NT-pro BNP, APN and ADH levels, which has exact curative effect.