目的 探討金蓮花顆粒聯(lián)合頭孢克肟治療小兒急性呼吸道感染的臨床療效。方法 選取儋州市人民醫(yī)院2015年9月—2016年9月收治的急性呼吸道感染患兒176例，隨機分成對照組和治療組，每組各88例。對照組患兒口服頭孢克肟顆粒，體質(zhì)量≥30 kg患兒，100 mg/次，體質(zhì)量<30 kg患兒，3 mg/kg，2次/d；治療組在對照組的基礎(chǔ)上口服金蓮花顆粒，每次1/3～1/2袋，3次/d。所有患兒均規(guī)律治療5 d。觀察兩組患者臨床療效，比較治療前后兩組患兒IL-8、C反應(yīng)蛋白（CRP）和降鈣素原（PCT）水平以及主要臨床癥狀消失時間和不良反應(yīng)情況。結(jié)果 治療后，對照組臨床總有效率為87.50%，顯著低于治療組的97.73%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組IL-8、CRP和PCT血清水平均較治療前顯著降低（P<0.05）；且治療組IL-8、CRP和PCT水平明顯低于對照組（P<0.05）。治療后，治療組患兒體溫恢復(fù)時間和咳嗽消失時間均顯著短于對照組患兒，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療期間，對照組不良反應(yīng)發(fā)生率為12.50%，明顯高于治療組的3.41%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 金蓮花顆粒聯(lián)合頭孢克肟治療小兒急性呼吸道感染療效顯著，安全性好，具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical effect of Jinlianhua Granules combined with cefixime in treatment of acute respiratory tract infection in children. Methods Children (176 cases) with acute respiratory tract infection in Danzhou People's Hospital from September 2015 to September 2016 were randomly divided into control and treatment groups, and each group had 88 cases. Children in the control group were po administered with Cefixime Granules, 100 mg/time for children weighed more than 30 kg, and 3 mg/kg for children weighed less than 30 kg, twice daily. Children in the treatment group were po administered with Jinlianhua Granules on the basis of the control group, 1/3-1/2 bag/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and IL-8, CRP and PCT levels, the disappearance time of main clinical symptoms, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 87.50%, which was significantly lower than 97.73% in the treatment group, with significant difference between two groups (P < 0.05). After treatment, IL-8, CRP, and PCT levels in two groups were significantly decreased (P < 0.05). And the IL-8, CRP, and PCT levels in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the temperature recovering time and coughing disappearance time in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). During the treatment, the incidence of adverse reactions in the control group was 12.50%, which was significantly higher than 3.41% in the treatment group, with significant difference between two groups (P < 0.05). Conclusion Jinlianhua Granules combined with cefixime has significant effect in treatment of acute respiratory tract infection in children with high safety, which has a certain clinical application value.