目的 探討小兒肺熱咳喘口服液聯(lián)合熱毒寧注射液治療兒童毛細支氣管炎的臨床效果。方法 選取重慶市大足區(qū)人民醫(yī)院2016年4月—2017年8月收治的毛細支氣管炎患兒108例，隨機分成對照組（54例）與治療組（54例）。對照組靜脈滴注熱毒寧注射液，0.5 mL/（kg·d）加入生理鹽水100 mL中，滴速為30～40滴/min，1次/d。治療組在對照組基礎(chǔ)上口服小兒肺熱咳喘口服液，4～7歲患兒10 mL/次，4次/d，8～12歲患兒20 mL/次，3次/d。兩組患兒連續(xù)治療7 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀體征消失時間、不同時段毛細支氣管炎評分和肺功能改善情況。結(jié)果 治療后，對照組和治療組的臨床總有效率分別為83.33%和96.30%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，治療組患兒喘息、肺部濕啰音、咳嗽和痰鳴音消失時間明顯短于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療2、3、7 d后，治療組毛細支氣管炎嚴重度評分均分別顯著低于相同時間的對照組患兒，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患兒潮氣量（TV）、達峰時間比（TPTEF/TE）均有明顯增加，呼吸頻率（RR）均有明顯下降，同組比較差異具有統(tǒng)計學意義（P<0.05）；且治療組患兒肺功能指標明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結(jié)論 小兒肺熱咳喘口服液聯(lián)合熱毒寧注射液治療兒童毛細支氣管炎可顯著促進患兒癥狀體征的緩解，改善患兒肺功能，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Xiao'er Feire Kechuan Oral Solution combined with Reduning Injection in treatment of bronchiolitis in children. Methods Children (108 cases) with bronchiolitis in Chongqing Dazu District People's Hospital from April 2016 to August 2017 were randomly divided into control (54 cases) and treatment (54 cases) groups. Children in the control group were iv administered with Reduning Injection, 0.5 mL/(kg·d) added into normal saline 100 mL, and the dropping speed was 30-40 drops/min, once daily. Children in the treatment group were po administered with Xiaoer Reke Oral Liquid on the basis of the control group, 10 mL/time for children at 4-7 years old, four times daily, 20 mL/time for children at 8-12 years old, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy were evaluated, and the improvement of the disappearance time of symptoms and signs, bronchiolitis scores and lung function in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.33% and 96.30%, respectively, and there were differences between two groups (P < 0.05). After treatment, the disappearance time of wheezing, lung rales, coughing and phlegm sound in the treatment group was significantly earlier than that in the control group, with significant difference between two groups (P < 0.05). After treatment for 2, 3, and 7 d, the bronchiolitis scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the TV and TPTEF/TE in two groups were significantly increased, RR was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the lung function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Xiao'er Feire Kechuan Oral Solution combined with Reduning Injection can significantly improve the symptoms and signs in treatment of bronchiolitis in children, and improve lung function, which has a certain clinical application value.

西安醫(yī)學院護理學省級重點學科建設(shè)項目（16hlxk19）