目的 探討克銀丸聯(lián)合阿維A膠囊治療銀屑病的臨床療效。方法 選取2016年2月—2017年2月在河南省職工醫(yī)院診治的銀屑病患者78例，隨機分為對照組（39例）和治療組（39例）。對照組患者口服阿維A膠囊，10 mg/次，3次/d。治療組在對照組的基礎(chǔ)上口服克銀丸，10 g/次，2次/d。兩組患者均經(jīng)過8周治療。觀察兩組患者臨床療效，比較治療前后兩組患者銀屑病面積與嚴(yán)重性指數(shù)（PASI）評分、血清學(xué)指標(biāo)和脂代謝指標(biāo)。結(jié)果 治療后，對照組的總有效率為74.36%，顯著低于治療組的92.31%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組PASI評分均明顯降低（P<0.05）；且治療組PASI評分比對照組更低（P<0.05）。治療后，兩組血清白細(xì)胞介素-17（IL-17）、血管內(nèi)皮生長因子（VEGF）、γ-干擾素（IFN-γ）、丙二醛（MDA）和脂質(zhì)過氧化產(chǎn)物（LPO）水平均顯著降低，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組上述血清學(xué)指標(biāo)顯著低于對照組（P<0.05）。治療后，兩組患者血清高密度脂蛋白膽固醇（HDL-C）水平均明顯升高（P<0.05）；載脂蛋白A1（ApoA1）、低密度脂蛋白膽固醇（LDL-C）顯著降低（P<0.05）；且治療組比對照組改善的更顯著（P<0.05）。結(jié)論 克銀丸聯(lián)合阿維A膠囊治療銀屑病可有效降低機體炎癥反應(yīng)，改善機體血脂代謝水平和氧化應(yīng)激狀態(tài)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Keyin Pills combined with Acitretin Capsules in treatment of psoriasis. Methods Patients (78 cases) with psoriasis in Henan Staff Hospital from February 2016 to February 2017 were randomly divided into control (39 cases) and treatment (39 cases) groups. Patients in the control group were po administered with Acitretin Capsules, 10 mg/time, three times daily. Patients in the treatment group were po administered with Keyin Pills on the basis of the control group, 10 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and PASI scores, serological indexes, and lipid metabolism indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 74.36%, which was significantly lower than 92.31% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the PASI scores in two groups were significantly decreased (P < 0.05). And the PASI scores in the treatment group were significantly lower than that in the control group (P < 0.05). After treatment, IL-17, VEGF, and IFN-γ, MDA and LPO levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the serological indexes in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the HDL-C in two groups was significantly increased (P < 0.05), but ApoA1 and LDL-C levels was significantly decreased (P < 0.05). And the level of these indexes in the treatment group was significantly better than that in the control group (P < 0.05). Conclusion Keyin Pills combined with Acitretin Capsules in treatment of psoriasis can effectively reduce inflammation, and improve the level of blood lipid metabolism and oxidative stress, which has a certain clinical application value.