目的 探討羥氯喹聯(lián)合復(fù)方倍他米松治療口腔扁平苔蘚的有效性與安全性。方法 選取2015年11月—2016年11月在邯鄲市口腔醫(yī)院治療的口腔扁平苔蘚患者125例，根據(jù)用藥方案不同分成對(duì)照組（62例）和治療組（63例）。對(duì)照組患者于病變黏膜處多點(diǎn)注射復(fù)方倍他米松注射液，1 mL加入2%利多卡因1 mL，1次/周；治療組患者在對(duì)照組的基礎(chǔ)上口服硫酸羥氯喹片，2片/次，2次/d。兩組患者均經(jīng)過(guò)6個(gè)月治療。觀察兩組患者臨床療效，比較治療前后兩組患者IL-17、γ-干擾素（IFN-γ）和IL-4水平以及視覺(jué)模擬（VAS）評(píng)分。結(jié)果 治療后，對(duì)照組臨床總有效率為83.87%，顯著低于治療組的96.83%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對(duì)照組復(fù)發(fā)率為22.58%，顯著高于治療組的7.94%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清IL-17、IL-4水平均顯著降低，血清IFN-γ水平顯著升高，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組IL-17、IFN-γ和IL-4水平明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者VAS評(píng)分均顯著降低（P<0.05）；且治療組降低更明顯，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 硫酸羥氯喹聯(lián)合復(fù)方倍他米松治療口腔扁平苔蘚療效較好，復(fù)發(fā)率低，安全性高，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the efficacy and safety of hydroxychloroquine combined with Compound Betamethasone Injection in treatment of oral lichen planus. Methods Patients (125 cases) with oral lichen planus in Handan Stomatological Hospital from November 2015 to November 2016 were divided into control (62 cases) and treatment (63 cases) groups based on different treatments. Patients in the control group were multipoint injection administered with Compound Betamethasone Injection at the lesion's mucosa, 1 mL added into 2% lidocaine 1 mL, once weekly. Patients in the treatment group were po administered with Hydroxychloroquine Sulfate Tablets on the basis of the control group, 2 tablets/time, twice daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacy was evaluated, and the IL-17, IFN-γ and IL-4 level, and VAS scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 83.87%, which was significantly lower than 96.83% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the recurrence rate in the control group was 22.58%, which was significantly higher than 7.94% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, IL-17 and IL-4 levels in two groups were significantly decreased, but IFN-γ levels were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And IL-17, IFN-γ and IL-4 levels in the treatment group was significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the VAS scores in two groups were significantly decreased (P < 0.05). And the VAS scores in the treatment group were significantly lower than that in the control group (P < 0.05). Conclusion Hydroxychloroquine combined with Compound Betamethasone Injection has good efficacy in treatment of oral lichen planus with low recurrence rate and high safety, which has a certain clinical application value.

邯鄲市科學(xué)技術(shù)局項(xiàng)目（1528108079-4）