目的 探討醒腦靜注射液聯(lián)合注射用鹽酸甲氯芬酯治療急性酒精中毒的臨床療效。方法 選取2016年6月—2017年6月赤峰市醫(yī)院收治的急性酒精中毒患者117例作為研究對象，所有患者在隨機分組的原則下分為對照組（58例）和治療組（59例）。對照組靜脈滴注注射用鹽酸甲氯芬酯，0.2 g加入到5%葡萄糖溶液250 mL中，3次/d。治療組在對照組的基礎上靜脈滴注醒腦靜注射液，20 mL加入到5%葡萄糖溶液500 mL中，1次/d。兩組患者均治療3 d。觀察兩組的臨床療效，比較兩組的蘇醒時間、中毒癥狀消失時間、運動功能恢復時間、氧代謝指標、血清氧化應激指標和蘇醒后不適癥狀。結果 治療后，對照組和治療組的總有效率分別為81.03%、96.61%，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療后，治療組蘇醒時間、中毒癥狀消失時間和運動功能恢復時間明顯短于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組血氧飽和度、動脈血氧、超氧化物歧化酶和谷胱甘肽過氧化物酶水平均顯著升高，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標明顯高于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療蘇醒后，對照組和治療組的不適癥狀發(fā)生率分別為43.10%、13.56%，兩組比較差異有統(tǒng)計學意義（P<0.05）。結論 醒腦靜注射液聯(lián)合注射用鹽酸甲氯芬酯治療急性酒精中毒具有較好的臨床療效，能縮短蘇醒時間、中毒癥狀消失時間和運動功能恢復時間，調節(jié)氧代謝指標和血清氧化應激指標，減輕患者蘇醒后的不適癥狀，具有一定的臨床推廣應用價值。

Objective To explore the clinical effect of Xingnaojing Injection combined with Meclofenoxate Hydrochloride for injection in treatment of acute alcoholism. Methods Patients (117 cases) with acute alcoholism in Chifeng Municipal Hospital from June 2016 to June 2017 were randomly divided into the control group (58 cases) and the treatment group (59 cases). Patients in the control group were iv administered with Meclofenoxate Hydrochloride for injection, 0.2 g added into 5% glucose solution 250 mL, three times daily. Patients in the treatment group were iv administered with Xingnaojing Injection on the basis of the control group, 20 mL added into 5% glucose solution 500 mL, once daily. Patients in two groups were treated for 3 d. After treatment, the clinical efficacies were evaluated, and revive time, poisoning symptoms disappeared time, exercise function recovery time, oxygen metabolism indexes, serum oxidative stress indexes, and discomfort symptoms after awakening in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.03% and 96.61%, respectively, and there was difference between two groups (P < 0.05). After treatment, revive time, poisoning symptoms disappeared time, and exercise function recovery time in the treatment group were obviously shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the levels of blood oxygen saturation, arterial oxygen content, superoxide dismutase, and glutathione peroxidase in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the incidence of discomfort symptoms in the control and treatment groups were 43.10% and 13.56%, respectively, and there was difference between two groups (P < 0.05). Conclusion Xingnaojing Injection combined with Meclofenoxate Hydrochloride for injection has clinical curative effect in treatment of acute alcoholism, can shorten revive time, poisoning symptoms disappeared time, and exercise function recovery time, regulate oxygen metabolism indexes and serum oxidative stress indexes, relieve the discomfort symptoms after awakening, which has a certain clinical application value.