目的 分析2014—2016年成都地區(qū)25家醫(yī)院質子泵抑制劑（PPIs）的使用情況，為臨床合理用藥提供參考。方法 抽取成都地區(qū)25家醫(yī)院2014—2016年PPIs的使用數(shù)據(jù)，對銷售金額、用藥頻度（DDDs）、日均費用（DDC）和排序比（B/A）等進行回顧性分析。結果 2014—2016年成都地區(qū)25家醫(yī)院PPIs的銷售金額連續(xù)3年呈遞減趨勢，同時總DDDs先增加后減少，2016年呈現(xiàn)最低值?？诜怭PIs以雷貝拉唑鈉位居DDDs排名的第1位，注射類PPIs中以注射用泮托拉唑鈉連續(xù)3年均穩(wěn)居銷售金額和DDDs排名的第1位。口服類PPIs中艾普拉唑的DDC最大，且同步性較好。注射類PPIs以艾司奧美拉唑的DDC最大，在同步性方面，泮托拉唑同步性最好。結論 通過加強合理用藥監(jiān)控手段，成都地區(qū)25家醫(yī)院PPIs的使用量得到有效控制，使用日趨合理化。

Objective To investigate the utilization of proton pump inhibitors (PPIs) in 25 hospitals in Chengdu area from 2014 to 2016, and to provide reference for clinical rational drug use. Methods Data of PPIs in 25 hospitals in Chengdu area from 2014 to 2016 were selected, and consumption sum, frequency of drug use (DDDs), defined daily cost (DDC), and sequence ratio (B/A) of PPIs were retrospectively analyzed. Results Consumption sum of PPIs in 25 hospitals in Chengdu area from 2014 to 2016 showed a decreasing trend for three consecutive years. Total DDDs was increased firstly and then decreased, and showed a minimum in 2016. DDDs of rabeprazole sodium in oral preparation ranked the first. Consumption sum and DDDs of Pantoprazole Sodium for injection in PPIs for injection ranked the first for three consecutive years. DDC of ilaprazole in oral preparation was the biggest with better synchronism. DDC of esomeprazole in PPIs for injection was the biggest, while the synchronism of pantoprazole was best. Conclusion By strengthening the monitoring methods of rational drug use, the use of PPIs in 25 hospitals in Chengdu area has been effectively controlled, and has become more and more rationalized.

四川省教育廳科研項目（16ZA0290）