柴胡皂苷是傳統(tǒng)中藥柴胡的主要生物活性成分，具有抗腫瘤、抗氧化損傷、抗纖維化和免疫調(diào)節(jié)等作用。目前已有大量文獻(xiàn)報(bào)道了有關(guān)柴胡皂苷抗腫瘤作用的研究成果，其抗腫瘤的作用機(jī)制主要包括誘導(dǎo)腫瘤細(xì)胞凋亡與分化、抑制腫瘤血管生長、抑制腫瘤侵襲轉(zhuǎn)移、逆轉(zhuǎn)腫瘤細(xì)胞多藥耐藥、免疫調(diào)節(jié)作用、聯(lián)合放化療減毒增敏效應(yīng)、調(diào)控腫瘤細(xì)胞自噬以及抑制環(huán)氧合酶等，其中誘導(dǎo)腫瘤細(xì)胞凋亡是通過抑制腫瘤細(xì)胞增殖、影響腫瘤基因表達(dá)、抑制腫瘤細(xì)胞分裂以及細(xì)胞毒作用實(shí)現(xiàn)的。通過查閱國內(nèi)外研究文獻(xiàn)，對(duì)柴胡皂苷的抗腫瘤作用進(jìn)行綜述。

Saikosaponins are the main bioactive ingredients of traditional Chinese medicine Radix Bupleuri, and have the effects of antitumor, anti-oxidative damage, anti-fibrosis, and immune regulation. At present, a large number of literatures have reported the research results of the antitumor effect of saikosaponin, and the mechanism of action mainly includes induction of apoptosis and differentiation of tumor cells, inhibition of tumor vascular growth, inhibition of tumor invasion and metastasis, reversal of multidrug resistance in tumor cells, immunomodulatory effect, hypersensitivity and sensitization effect of combined radiotherapy and chemotherapy, regulation of autophagy in tumor cells, and inhibition of cyclooxygenase, etc. Apoptosis is induced by inhibiting tumor cell proliferation, affecting tumor gene expression, inhibiting cell division, and cytotoxicity. This study gives a brief review on the antitumor effect of saikosaponins by consulting references at home and abroad.