目的 探討銀杏葉提取物注射液聯(lián)合腦苷肌肽注射液治療急性腦梗死的臨床療效。方法 選取2016年9月—2017年9月在濮陽市安陽地區(qū)醫(yī)院進(jìn)行治療的急性腦梗死患者168例為研究對(duì)象，所有患者根據(jù)治療方法的差別分為對(duì)照組和治療組，每組各84例。對(duì)照組靜脈滴注腦苷肌肽注射液，16 mL加入到5%葡萄糖注射液250 mL中，1次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注銀杏葉提取物注射液，20 mL加入到5%葡萄糖注射液250 mL中，1次/d。兩組均連續(xù)治療2周。觀察兩組的臨床療效，比較兩組的血清學(xué)指標(biāo)、血液流變學(xué)指標(biāo)和美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NIHSS）評(píng)分。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為84.52%、97.62%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清人神經(jīng)膠質(zhì)纖維酸性蛋白（GFAP）、親環(huán)素A（CyPA）、血小板活化因子（PAF）、單核細(xì)胞趨化蛋白-1（MCP-1）、同型半胱氨酸（Hcy）水平均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組紅細(xì)胞壓積（HCT）、全血黏度（WBV）、纖維蛋白原（FIB）、血漿黏度（PV）水平均明顯下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組NIHSS評(píng)分均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組NIHSS評(píng)分明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 銀杏葉提取物注射液聯(lián)合腦苷肌肽注射液治療急性腦梗死具有較好的臨床療效，可改善機(jī)體細(xì)胞因子水平和血液流變學(xué)指標(biāo)，有利于神經(jīng)功能恢復(fù)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Ginkgo Biloba Leaves Injection combined with Cattle Encephalon Glycoside and Ignotin Injection in treatment of acute cerebral infarction. Methods Patients (168 cases) with acute cerebral infarction in Puyang Anyang District Hospital from September 2016 to September 2017 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 84 cases. Patients in the control group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection, 16 mL added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were iv administered with Extract of Ginkgo Biloba Leaves Injection on the basis of the control group, 20 mL added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and serological indexes, hemorheological indexes, and NIHSS score in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.52% and 97.62%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of GFAP, CyPA, PAF, MCP-1, and Hcy in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of HCT, WBV, FIB, and PV in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the NIHSS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the NIHSS score in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Ginkgo Biloba Leaves Injection combined with Cattle Encephalon Glycoside and Ignotin Injection has clinical curative effect in treatment of acute cerebral infarction, can improve cytokine levels and hemorheological indexes, be beneficial to the recovery of nerve function, which has a certain clinical application value.