目的 探討乳酸依沙吖啶注射液聯(lián)合米非司酮片和米索前列醇片治療中期妊娠引產(chǎn)的臨床療效。方法 選取2013年9月—2017年3月安陽(yáng)市人民醫(yī)院婦產(chǎn)科收治的中期妊娠引產(chǎn)患者132例為研究對(duì)象，將所有患者分為依沙吖啶組（A組，44例）、米非司酮聯(lián)合米索前列醇組（B組，41例）和依沙吖啶聯(lián)合米非司酮和米索前列醇組（C組，47例）。A組腹部注射位點(diǎn)采用腰穿針行羊膜腔穿刺，注入乳酸依沙吖啶注射液100 mg。B組口服米非司酮片，50 mg/次，2次/d，連續(xù)3 d，第4天陰道后穹窿放置米索前列醇片0.4 mg。C組口服米非司酮片100 mg/次，1 h后采用腰穿針行羊膜腔穿刺，注入乳酸依沙吖啶注射液100 mg，12 h后陰道后穹窿放置米索前列醇片0.4 mg。觀察各組患者的引產(chǎn)效果，比較術(shù)中及術(shù)后情況。結(jié)果 3組引產(chǎn)成功率比較差異無(wú)統(tǒng)計(jì)學(xué)意義。A、B、C組清宮率分別為36.36%、29.27%、12.77%，C組清宮率明顯低于A、B組，3組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。C組用藥至宮縮時(shí)間、引產(chǎn)時(shí)間、產(chǎn)后2 h出血量、產(chǎn)后出血天數(shù)、胎盤(pán)殘留率顯著低于A、B組，3組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。C組1級(jí)疼痛程度明顯高于A、B組，3、4級(jí)疼痛程度明顯低于A、B組，3組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。3組患者復(fù)潮時(shí)間、經(jīng)期持續(xù)時(shí)間相當(dāng)，沒(méi)有統(tǒng)計(jì)學(xué)差異。結(jié)論 乳酸依沙吖啶注射液聯(lián)合米非司酮片和米索前列醇片治療中期妊娠引產(chǎn)具有較好的臨床效果，可降低清宮率和胎盤(pán)殘留率，縮短用藥至宮縮時(shí)間、引產(chǎn)時(shí)間，減少出現(xiàn)量和出血天數(shù)，具有一定臨床推廣應(yīng)用價(jià)值。

Objective To evaluate the clinical effect of Ethacridine Lactate Injection combined with Mifepristone Tablets and Misoprostol Tablets in treatment of midterm pregnancy induced labor. Methods Patients (132 cases) with midterm pregnancy induced labor in Anyang People's Hospital from September 2013 to March 2017 were divided into ethacridine group (A group, 44 cases), mifepristone combined with misoprostol group (B group, 41 cases), and ethacridine combined with mifepristone and misoprostol group (C group, 47 cases). Patients in A group were lumbar puncture needle underwent amniocentesis in abdominal injection site, and be injected Ethacridine Lactate Injection 100 mg. Patients in B group were po administered with Mifepristone Tablets, 50 mg/time, twice daily, and continuously treated for 3 d. At 4th day, Misoprostol Tablets 0.4 mg were placed on the posterior fornix vagina. Patients in C group were po administered with Mifepristone Tablets 100 mg/time, then injected Ethacridine Lactate Injection 100 mg, and placed with Misoprostol Tablets 0.4 mg on the posterior fornix vagina after 12 h. After treatment, labor induction were evaluated, and intraoperative and postoperative conditions in three groups were compared. Results There were no significant differences in success rate of induced labor among three groups. The curettage rates in A, B, and C groups were 36.36%, 29.27% and 12.77%, respectively, and the curettage rates in C group were significantly lower than that in A and B groups, and there was difference among three groups (P < 0.05). The time of drug use to uterine contraction, time of induced labor, 2 h postpartum hemorrhage, the number of bleeding days, and placental residual rate in C group were significantly lower than those in A and B groups, and there was difference among three groups (P < 0.05). The grade 1 of pain degree in C group was significantly higher than those in A and B groups, but the grade 3 and 4 of pain degree in C group was significantly lower than those in A and B groups, and there was difference among three groups (P < 0.05). Conclusion Ethacridine Lactate Injection combined with Mifepristone Tablets and Misoprostol Tablets has clinical curative effect in treatment of midterm pregnancy induced labor, can decrease the curettage rate and placental residual rate, shorten the time of drug use to uterine contraction and time of induced labor, reduce the amount of appearance and the number of bleeding days, which has a certain clinical application value.