目的 探討丹參川芎嗪注射液聯(lián)合注射用尿激酶治療急性心肌梗死的臨床療效。方法 選擇2016年6月—2017年7月在宣城市中心醫(yī)院治療的急性心肌梗死患者65例為研究對象，按照患者所用治療方案差異將所有患者分為對照組（33例）和治療組（32例）。對照組給予注射用尿激酶，先靜脈推注，50萬單位加入到5%葡萄糖溶液20 mL中，而后更改為靜脈滴注，50萬單位加入到5%葡萄糖液500 mL中，1次/d。治療組在對照組的基礎上靜脈滴注丹參川芎嗪注射液，10 mL加入到生理鹽水500 mL中，1次/d。兩組患者均連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組的心功能指標和血管再通情況。結果 治療后，對照組和治療組的總有效率分別為75.76%、87.50%，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。治療后，兩組左室射血分數(shù)（LVEF）、每搏心輸出量（SV）均明顯升高，中心靜脈壓（CVP）明顯降低，同組治療前后比較差異具有統(tǒng)計學意義（P < 0.05）；且治療組這些觀察指標的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。治療后，對照組和治療組的血管再通率分別為57.58%、84.38%，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。結論 丹參川芎嗪注射液聯(lián)合注射用尿激酶治療急性心肌梗死具有較好的臨床療效，可改善心臟功能，提高血管再通率，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Urokinase for injection in treatment of acute myocardial infarction. Methods Patients (65 cases) with acute myocardial infarction in Xuancheng City Central Hospital from June 2016 to July 2017 were randomly divided into the control group (33 cases) and the treatment group (32 cases). Patients in the control group were given Urokinase for injection, first intravenous injection, 50 000 units added into 5% glucose solution 20 mL, then change to intravenous drip, 50 000 units added into 5% glucose solution 500 mL, once daily. Patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 10 mL added into normal saline 500 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and cardiac function indexes and vascular recanalization in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 75.76% and 87.50%, respectively, and there was difference between two groups (P < 0.05). After treatment, LVEF and SV in two groups were significantly increased, but CVP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the vascular recanalization rates in the control and treatment groups were 57.58% and 84.38%, respectively, and there was difference between two groups (P < 0.05). Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Urokinase for injection has clinical curative effect in treatment of acute myocardial infarction, can improve cardiac function, and increase vascular recanalization rate, which has a certain clinical application value.