目的 探討玉屏風顆粒聯(lián)合多索茶堿治療兒童喘息性支氣管炎的臨床效果。方法 選擇竹山縣人民醫(yī)院2016年1月—2017年3月收治的喘息性支氣管炎患兒108例，隨機分成對照組（54例）與治療組（54例）。對照組患兒靜脈滴注注射用多索茶堿，4 mg/kg加入5%葡萄糖注射液50 mL，1次/d。治療組在對照組的基礎上口服玉屏風顆粒，1袋/次，3次/d。兩組患兒均連續(xù)治療14 d。觀察兩組患兒臨床療效，比較治療前后兩組患兒癥狀體征消失時間和住院時間及免疫功能和治療后3、6個月復發(fā)率。結果 治療后，對照組臨床總有效率為77.78%，顯著低于治療組的96.30%，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。治療后，治療組癥狀體征消失時間和住院時間均比對照組明顯縮短，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。治療后，兩組IgE明顯降低，CD⁴⁺、CD⁴⁺/CD⁸⁺明顯升高，治療組CD⁸⁺明顯下降，同組比較差異具有統(tǒng)計學意義（P < 0.05），且治療組免疫功能均明顯優(yōu)于對照組（P < 0.05）。治療3、6個月后，治療組復發(fā)率分別為1.85%、3.70%，均明顯低于同期對照組的20.37%、25.93%，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。結論 玉屏風顆粒聯(lián)合多索茶堿治療兒童喘息性支氣管炎能有效促進癥狀體征的緩解，提高患兒的免疫功能，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Yupingfeng Granules combined with doxofylline in treatment of asthmatic bronchitis in children. Methods Children (108 cases) with asthmatic bronchitis in Zhushan People's Hospital from January 2016 to March 2017 were randomly divided into control (54 cases) and treatment (54 cases) groups. Children in the control group were iv administered with Doxofylline for injection, 4 mg/kg added into 5% glucose solution 50 mL, once daily. Children in the treatment group were po administered with Yupingfeng Granules on the basis of the control group, 1 bag/time, three times daily. Children in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of symptoms and signs, hospitalization time, immune function, and the recurrence rate at 3 and 6 months in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 77.78%, which was significantly lower than 96.30% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the disappearance time of symptoms and signs, hospitalization time in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the IgE level in two groups was significantly decreased, but CD⁴⁺ and CD⁴⁺/CD⁸⁺ in two groups were significantly increased, CD⁸⁺ in the treatment group was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the immune function in the treatment group was significantly better than that in the control group (P < 0.05). After treatment, the recurrence rate at 3 and 6 months in the treatment group were 1.85% and 3.70%, which were significantly lower than 20.37% and 25.93% in the control group, respectively, and there were differences between two groups (P < 0.05). Conclusion Yupingfeng Granules combined with doxofylline in treatment of asthmatic bronchitis in children can effectively promote the remission of symptoms and signs and improve the immune function, which has a certain clinical application value.