目的 觀察百令膠囊聯合別嘌醇治療痛風性腎病的臨床療效。方法 選取2015年6月—2016年12月在天津中醫(yī)藥大學第一附屬醫(yī)院老年病科就診的56例痛風性腎病患者，隨機分為對照組和治療組，每組各28例，對照組患者口服別嘌醇緩釋膠囊，0.25 g/次，1次/d。治療組患者在對照組的基礎上口服百令膠囊，4粒/次，3次/d。兩組患者均治療8周。觀察兩組患者的臨床療效，比較治療前后兩組患者尿素氮（BUN）、肌酐（Cr）、血尿酸（UA）、24 h尿蛋白定量以及外周血淋巴細胞亞群水平。結果 治療后，對照組和治療組的總有效率分別為71.43%、89.29%，兩組比較差異有統(tǒng)計學意義（P < 0.05）。兩組BUN、Cr、UA和24 h尿蛋白水平均較治療前降低，同組治療前后差異有統(tǒng)計學意義（P < 0.05）；且治療后治療組上述指標均低于對照組，兩組比較差異有統(tǒng)計學意義（P < 0.05）。治療后，治療組CD³⁺、CD³⁺/CD⁴⁺、CD³⁺/CD⁸⁺和CD^3-/CD¹⁶⁺⁵⁶⁺升高，CD^3-/CD¹⁹⁺和CD⁴⁺/CD⁸⁺降低，同組治療前后比較差異有統(tǒng)計學意義（P < 0.05）；且治療后治療組外周血淋巴細胞亞群水平均優(yōu)于對照組，兩組比較差異有統(tǒng)計學意義（P < 0.05）。結論 百令膠囊聯合別嘌醇治療痛風性腎病具有較好的臨床療效，可以明顯改善患者的臨床癥狀，提高腎功能，調節(jié)細胞免疫紊亂，且安全性較好，具有一定的臨床應用價值。

Objective To observe the clinical efficacy of Bailing Capsules combined with allopurinol in treatment of gouty nephropathy. Methods Patients (28 cases) with gouty nephropathy in Department of Geriatric of First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from June 2015 to December 2016 were randomly divided into control and treatment groups, and each group had 28 cases. Patients in the control group were po administered with Allopurinol Sustained-release Capsules, 0.25 g/time, once daily. Patients in the treatment group were po administered with Bailing Capsules, 4 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and BUN, Cr, UA, and 24 h urine protein excretion, and peripheral blood lymphocytes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.43% and 89.29%, respectively, and there was difference between two groups (P < 0.05). After treatment, BUN, Cr, UA, and 24 h urine protein excretion in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, CD³⁺, CD³⁺/CD⁴⁺, CD³⁺/CD⁸⁺, and CD^3-/CD¹⁶⁺⁵⁶⁺ in the treatment group were significantly increased, while CD³⁺/CD¹⁹⁺ and CD⁴⁺/CD⁸⁺were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the peripheral blood lymphocytes indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Bailing Capsules combined with allopurinol has clinical curative effect in treatment of gouty nephropathy, can improve clinical symptoms and renal function, and regulate cellular immune disorders with good safety, which has a certain clinical application value.