白細(xì)胞介素35（IL-35）是近年發(fā)現(xiàn)并命名的IL-12家族細(xì)胞因子，它可由調(diào)節(jié)性T（Treg）細(xì)胞和調(diào)節(jié)性B（Breg）細(xì)胞特異性產(chǎn)生，是Treg和Breg細(xì)胞介導(dǎo)的負(fù)向免疫調(diào)節(jié)作用所必需的細(xì)胞因子。研究表明IL-35在器官移植免疫中發(fā)揮重要作用，針對(duì)IL-35的臨床研發(fā)藥物及細(xì)胞藥物治療可為抗移植排斥反應(yīng)甚至誘導(dǎo)移植免疫耐受提供新的靶點(diǎn)和研究方向。

Interleukin 35 (IL-35) is a kind of cytokine which is recently found and belongs to the IL-12 family. IL-35 is a cytokine secreted by regulatory T cells (Treg) and regulatory B cells (Breg), and is necessary for the negative immunoregulation mediated by Treg and Breg cells. Studies have shown that IL-35 plays an important role in organ transplantation immunity. The clinical research development drugs and cell therapy drugs for IL-35 can provide new targets and research directions for anti-graft rejection and even induction of transplantation immunity tolerance.

天津醫(yī)科大學(xué)科學(xué)基金資助項(xiàng)目（2014KYM03）