目的 探討苦碟子注射液聯(lián)合腦苷肌肽治療急性腦梗死的臨床效果。方法 選取2015年9月-2017年9月皖南醫(yī)學(xué)院第二附屬醫(yī)院收治的86例急性腦梗死患者，隨機分為對照組和治療組，每組各43例。對照組靜脈滴注腦苷肌肽注射液，20 mL加入生理鹽水250 mL充分稀釋后給藥，緩慢滴注，1次/d。治療組在對照組基礎(chǔ)上靜脈滴注苦碟子注射液，40 mL加入生理鹽水250 mL均勻混合后給藥，1次/d。兩組均連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組治療前后國立衛(wèi)生研究院卒中量表（NIHSS）評分、日常生活能力量表（ADL）評分、頸總動脈內(nèi)徑（CCAD）、頸動脈內(nèi)-中膜厚度（CIMT）、椎動脈收縮期峰值（Vs）、舒張末期血流速度（Vd）、血清低/高密度脂蛋白膽固醇比值（LDL-C/HDL-C）、超敏C反應(yīng)蛋白（hs-CRP）、降鈣素原（PCT）、胱抑素C（Cys-C）、同型半胱氨酸（Hcy）的變化情況。結(jié)果 治療后，對照組和治療組的總有效率分別為72.09%、90.70%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組NIHSS、ADL評分、LDL-C/HDL-C值、hs-CRP、PCT、Cys-C、Hcy較治療前均顯著降低，兩組雙側(cè)椎動脈Vs、Vd值均顯著增加，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；治療后，治療組NIHSS、ADL評分、雙側(cè)CCAD、CIMT值、LDL-C/HDL-C值、hs-CRP、PCT、Cys-C、Hcy均顯著低于對照組，治療組雙側(cè)椎動脈Vs、Vd值顯著高于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 苦碟子注射液聯(lián)合腦苷肌肽治療急性腦梗死具有較好的臨床療效，可有效改善患者腦血流狀態(tài)，減輕組織損傷與頸動脈粥樣硬化病變，促進神經(jīng)功能恢復(fù)，提高生活質(zhì)量，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Kudiezi Injection combined with cattle encephalon glycoside and ignotin in treatment of acute cerebral infarction. Methods Patients (86 cases) with acute cerebral infarction in the Second Affiliated Hospital of Wannan Medical College from September 2015 to September 2017 were randomly divided into control (43 cases) and treatment (43 cases) groups. Patients in the control group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection, 20 mL was added with normal saline solution 250 mL, once daily. Patients in the treatment group were iv administered with Kudiezi Injection on the basis of the control group, 40 mL was added with normal saline solution 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the changes of NIHSS score, ADL score, CCAD, CIMT, Vs, Vd, LDL-C/HDL-C, hs-CRP, PCT, Cys-C, and Hcy in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 72.09% and 90.70%, respectively, and there was difference between two groups (P < 0.05). After treatment, NIHSS score, ADL score, LDL-C/HDL-C, hs-CRP, PCT, Cys-C, and Hcy in two groups were significantly reduced, butVs and Vd of both bilateral vertebral artery were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, NIHSS score, ADL score, CCAD and CIMT of both sides, LDL-C/HDL-C, hs-CRP, PCT, Cys-C, and Hcy in the treatment group were lower than those in the control group, but Vs and Vd of both bilateral vertebral artery were higher than those in the control group, and there was difference between two groups (P < 0.05). Conclusion Kudiezi Injection combined with cattle encephalon glycoside and ignotin has remarkable clinical effect in treatment of acute cerebral infarction, and can effectively improve the blood flow state, reduce tissue damage and carotid atherosclerosis, promote the recovery of nerve function and improve the life quality, which has a certain clinical application value.