目的 探討苦碟子注射液聯(lián)合納洛酮治療后循環(huán)缺血性眩暈的臨床效果。方法 選擇浚縣人民醫(yī)院2014年6月-2016年12月收治的94例后循環(huán)缺血性眩暈患者，隨機(jī)分成對照組和治療組，每組各47例。對照組靜脈滴注鹽酸納洛酮注射液，2.4 mg/次，1次/d。治療組在對照組的基礎(chǔ)上靜脈滴注苦碟子注射液，20 mL加入生理鹽水250 mL，1次/d。兩組患者均持續(xù)治療14 d。觀察兩組患者臨床療效，比較治療前后兩組患者內(nèi)皮功能、血流動力學(xué)、眩暈癥狀量表評分以及不良反應(yīng)情況。結(jié)果 治療后，對照組和治療組的臨床總有效率分別為78.22%、95.74%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組內(nèi)皮素-1（ET-1）、血管性血友病因子（vWF）、血栓調(diào)節(jié)蛋白（TM）均較治療前顯著降低，降鈣素基因相關(guān)肽（CGRP）均較治療前升高，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組內(nèi)皮功能明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組椎基底動脈、右側(cè)椎動脈和左側(cè)椎動脈指標(biāo)均較治療前顯著降低，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些血流動力學(xué)指標(biāo)明顯低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組眩暈癥狀量表評分均較治療前顯著降低，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組眩暈癥狀量表評分明顯低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 苦碟子注射液聯(lián)合納洛酮治療后循環(huán)缺血性眩暈的療效顯著，能夠有效糾正內(nèi)皮功能及血流動力學(xué)，促進(jìn)疾病的恢復(fù)，具有一定的臨床推廣應(yīng)用價值。

Objective To discuss the clinical effect of Kudiezi Injection combined with naloxone in treatment of posterior circulation ischemic dizziness. Methods Patients (94 cases) with posterior circulation ischemic dizziness in Junxian People's Hospital from June 2014 to December 2016 were randomly divided into controland treatment groups. Each group had 47 cases. Patients in the control group were iv administered with Naloxone Hydrochloride Injection, 2.4 mg/time, once daily. Patients in the treatment group were iv administered with Kudiezi Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and endothelial function, hemodynamics, vertigo symptom scale score, and adverse reactions in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control and treatment groups were 78.22% and 95.74%, respectively, and there were differences between two groups (P < 0.05). ET-1, vWF, and TM in two groups were significantly decreased, but CGRP was significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these endothelial function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Vertebrobasilar artery, right vertebral artery, and left vertebral artery indexes in two groups were significantly decreased, and there were differences between two groups (P < 0.05). And those hemodynamic indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). The vertigo symptom scale score in two groups was decreased (P < 0.05), and the score in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Kudiezi Injection combined with naloxone has good effect in treatment of posterior circulation ischemic dizziness, and can effectively correct endothelial function and hemodynamics, and promote the recovery of disease, which has a certain clinical application value.