目的 探討銀杏葉膠囊聯(lián)合單硝酸異山梨酯片治療冠心病心絞痛的臨床療效。方法 選取2015年2月-2016年12月青海省心腦血管病?？漆t(yī)院收治的冠心病心絞痛患者120例為研究對象，所有患者隨機分為對照組和治療組，每組各60例。對照組口服單硝酸異山梨酯片，10 mg/次，3次/d。治療組在對照組基礎(chǔ)上口服銀杏葉膠囊，1粒/次，3次/d。兩組患者均連續(xù)治療3個月。觀察兩組的心絞痛療效和心電圖療效，比較兩組的心絞痛發(fā)作和緩解情況、心絞痛積分情況、炎性因子和氧化應(yīng)激指標。結(jié)果 治療后，對照組和治療組的心絞痛療效總有效率分別為80.00%、93.33%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，對照組和治療組的心電圖療效總有效率分別為70.00%、86.67%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組心絞痛發(fā)作頻率、持續(xù)時間、緩解時間和硝酸甘油用量均顯著降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組心絞痛積分均顯著降低，同組治療前后比較差異具有統(tǒng)計學意義（P<0.05）；且治療組這些積分明顯抵于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組腫瘤壞死因子-α（TNF-α）、白細胞介素-6（IL-6）、C反應(yīng)蛋白（CRP）、丙二醛（MDA）水平顯著降低，超氧化物歧化酶（SOD）水平顯著升高，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結(jié)論 銀杏葉膠囊聯(lián)合單硝酸異山梨酯片治療冠心病心絞痛具有較好的臨床療效，可改善臨床癥狀，降低炎癥反應(yīng)和氧化應(yīng)激水平，具有一定的臨床推廣應(yīng)用價值。

Objective To study the effect of Yinxingye Capsules combined with Isosorbide Mononitrate Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients (120 cases) with angina pectoris of coronary heart disease in Qinghai Cardio Cerebrovascular Disease Specialist Hospital from February 2015 to December 2016 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Isosorbide Mononitrate Tablets, 10 mg/time, three times daily. Patients in the treatment group were po administered with Yinxingye Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies and electrocardiogram efficacies were evaluated, and the attack and relief of angina pectoris, angina pectoris symptoms, inflammatory factors, and oxidative stress indexes in two groups were compared. Results After treatment, the clinical efficacies of angina pectoris in the control and treatment groups were 80.00% and 93.33%, respectively, and there was difference between two groups (P < 0.05). After treatment, the electrocardiogram efficacies in the control and treatment groups were 70.00% and 86.67%, respectively, and there was difference between two groups (P < 0.05). After treatment, attack frequency, duration, the remission time of angina pectoris and the dosage of nitroglycerin in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, angina pectoris symptoms in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α, IL-6, CRP, and MDA in two groups were significantly decreased, but the levels of SOD in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Yinxingye Capsules combined with Isosorbide Mononitrate Tablets has clinical curative effect in treatment of angina pectoris of coronary heart disease, can improve clinical symptoms, decrease inflammatory response and oxidative stress level, which has a certain clinical application value.