目的 探討?zhàn)B胃顆粒聯(lián)合鋁碳酸鎂治療慢性萎縮性胃炎的臨床效果。方法 選取2016年1月-2017年12月廣元市第三人民醫(yī)院收治的慢性萎縮性胃炎患者106例，隨機(jī)分成對(duì)照組和治療組，每組各53例。對(duì)照組患者口服鋁碳酸鎂片，1.0 g/次，3次/d。治療組在對(duì)照組治療基礎(chǔ)上口服養(yǎng)胃顆粒，1袋/次，3次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效，比較兩組患者治療前后臨床癥狀積分、胃腸激素、胃蛋白酶原（PG）、白細(xì)胞介素-1β（IL-1β）、IL-12、人表皮生長(zhǎng)因子（hEGF）、氧化氫酶（CAT）活性、降鈣素基因相關(guān)肽（CGRP）、內(nèi)皮素（ET）的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為81.13%、94.34%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組胃痛積分、胃中嘈雜積分、胃脘脹滿積分、噯氣反酸積分、乏力積分均顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組治療后，這些癥狀積分均顯著低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清胃動(dòng)素（MTL）、PGⅡ、IL-1β、hEGF、ET較治療前均顯著降低，但胃泌素（GAS）、PGⅠ、PGⅠ/PGⅡ、IL-12、CAT、CGRP均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療后治療組MLT、PGⅡ、IL-1β、hEGF、ET低于對(duì)照組，GAS、PGⅠ、PGⅠ/PGⅡ、IL-12、CAT、CGRP高于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 養(yǎng)胃顆粒聯(lián)合鋁碳酸鎂治療慢性萎縮性胃炎具有較好的臨床療效，可明顯改善患者癥狀，調(diào)節(jié)胃腸激素分泌與氧化應(yīng)激狀態(tài)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Yangwei Granules combined with hydrotalcite in treatment of chronic atrophic gastritis. Methods Patients (106 cases) with chronic atrophic gastritis in the Third People's Hospital of Guangyuan from January 2016 to December 2017 were randomly divided into control (53 cases) and treatment (53 cases) groups. Patients in the control group were po administered with Hydrotalcite Tablets, 1.0 g/time, three times daily. Patients in the treatment group were po administered with Yangwei Granules, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of clinical symptoms integral, gastrointestinal hormone, PG, IL-1β, IL-12, hEGF, CAT, CGRP, and ET in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.13% and 94.34%, respectively, and there was difference between two groups (P < 0.05). After treatment, stomachache integral, noise in the stomach integral, diagnosis swelling integral, belching anti acid integral, lacking in strength integral significantly reduced, and the difference was statistically significant in the same group (P < 0.05). After treatment, these symptoms integrals were significantly lower than those in the control group, and there was difference between two groups (P < 0.05). After treatment, MLT, PGⅡ, IL-1β, hEGF, and ET in two groups significantly reduced, but GAS, PGⅠ, PGⅠ/PGⅡ, IL-12, CAT, and CGRP significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, MLT, PGⅡ, IL-1β, hEGF, and ET in the treatment group were lower than those in the treatment group, but GAS, PGⅠ, PGⅠ/PGⅡ, IL-12, CAT, and CGRP were higher, and there was difference between two groups (P < 0.05). Conclusion Yangwei Granules combined with hydrotalcite has remarkable clinical effect in treatment of chronic atrophic gastritis, and can obviously improve the symptoms, and can regulate the secretion and oxidative stress state of gastrointestinal hormones, which has a certain clinical application value.