目的 探討茵梔黃口服液聯(lián)合注射用硫普羅寧治療藥物性肝損傷的臨床療效。方法 選取2015年8月-2017年9月成都市新都區(qū)人民醫(yī)院收治的藥物性肝損傷患者100例為研究對(duì)象，根據(jù)隨機(jī)區(qū)組設(shè)計(jì)法將患者分為對(duì)照組和治療組，每組各50例。對(duì)照組靜脈滴注注射用硫普羅寧，400 mg加入到5%葡萄糖注射液500 mL中，1次/d。治療組在對(duì)照組基礎(chǔ)上口服茵梔黃口服液，10 mL/次，3次/d。兩組均連續(xù)治療1個(gè)月。觀察兩組的臨床療效，比較兩組的肝功能、臨床癥狀和炎性因子。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為72.0%、92.0%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組丙氨酸氨基轉(zhuǎn)移酶（ALT）、天冬氨酸氨基轉(zhuǎn)氨酶（AST）、總膽紅素（TBIL）水平均顯著下降，白蛋白（ALB）水平顯著升高，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些肝功能指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組腹脹、乏力、納差、黃疸、肝脾大改善率均顯著高于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清腫瘤壞死因子-α（TNF-α）、干擾素-γ（TNF-γ）水平顯著降低，血清白細(xì)胞介素-10（IL-10）水平顯著升高，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些炎癥因子的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 茵梔黃口服液聯(lián)合注射用硫普羅寧治療藥物性肝損傷具有較好的臨床療效，可改善患者的肝功能和臨床癥狀，降低炎性因子水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the effect of Yinzhihuang Oral Liquid combined with Tiopronin for injection in treatment of drug-induced liver injury. Methods Patients (100 cases) with drug-induced liver injury in Chengdu Xindu People's Hospital from August 2015 to September 2017 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were iv administered with Tiopronin for injection, 400 mg/time added into 5% glucose solution, once daily. Patients in the treatment group were po administered with Yinzhihuang Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacies were evaluated, and liver function, clinical symptoms, and inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 72.0% and 92.0%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of ALT, AST, and TBIL in two groups were significantly decreased, but the levels of ALB in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the liver function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the improvement rates of bloating, fatigue, anorexia, jaundice, and hepatosplenomegaly in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the levels of TNF-α and IFN-γ in two groups were significantly decreased, but the levels of IL-10 in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the inflammatory factors in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Yinzhihuang Oral Liquid combined with Tiopronin for injection has significant effect in treatment of drug-induced liver injury, can improve liver function and clinical symptoms, reduce the levels of inflammatory factors, which has a certain clinical application value.