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[摘要]
目的 探討甲亢靈膠囊聯(lián)合甲巰咪唑片治療甲狀腺功能亢進癥的臨床療效。方法 選取2015年10月-2017年3月成都市郫都區(qū)中醫(yī)醫(yī)院收治的甲狀腺功能亢進癥患者60例為研究對象,采用隨機數(shù)字表法將患者隨機分為對照組和治療組,每組各30例。對照組口服甲巰咪唑片,10 mg/次,3次/d。治療組在對照組的基礎上口服甲亢靈膠囊,4粒/次,3次/d,兩組患者均連續(xù)治療6周,隨訪半年。觀察兩組的臨床療效,比較兩組的甲狀腺功能指標。結果 治療后,對照組和治療組的總有效率分別為80.00%、96.67%,兩組比較差異具有統(tǒng)計學意義(P<0.05)。治療后,兩組游離型三碘甲狀腺原氨酸(FT3)、游離型甲狀腺素(FT4)水平均顯著下降,促甲狀腺激素(TSH)水平均顯著升高,同組治療前后比較差異具有統(tǒng)計學意義(P<0.05);且治療組這些甲狀腺功能指標的改善程度明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計學意義(P<0.05)。結論 甲亢靈膠囊聯(lián)合甲巰咪唑片治療甲狀腺功能亢進癥具有較好臨床療效,能改善甲狀腺功能,安全性較好,具有一定的臨床推廣應用價值。
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[Abstract]
Objective To investigate the clinical efficacy of Jiakangling Capsules combined with Thiamazole Tablets in treatment of hyperthyroidism. Methods Patients (60 cases) with hyperthyroidism in Chengdu Pidu District Hospital of Traditional Chinese Medicine from October 2015 to March 2017 were randomly divided into control and treatment groups, and each group had 30 cases. Patients in the control group were po administered with Thiamazole Tablets, 10 mg/time, three times daily. Patients in the treatment group were po administered with Jiakangling Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 6 weeks, then followed up for 6 months. After treatment, the clinical efficacies were evaluated, and the thyroid functions in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 96.67%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of FT3 and FT4 in two groups were significantly decreased, but the levels of TSH in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the thyroid function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Jiakangling Capsules combined with Thiamazole Tablets has a clinical curative effect in treatment of hyperthyroidism, can improve the thyroid function, with good safety, which has a certain clinical application value.
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