目的 探究甲亢靈膠囊聯(lián)合丙硫氧嘧啶片治療Graves病的臨床療效。方法 選取2015年2月-2017年1月于西電集團(tuán)醫(yī)院收治的Graves病患者134例為研究對象，所有患者按隨機(jī)數(shù)字表法分為對照組和治療組，每組各67例。對照組口服丙硫氧嘧啶片，起始劑量100 mg/次，3次/d，至臨床癥狀、甲狀腺功能改善后逐漸減量至50~100 mg/d。治療組在對照組治療基礎(chǔ)上口服甲亢靈膠囊，4粒/次，3次/d。兩組均連續(xù)治療6個(gè)月。觀察兩組的臨床療效，比較兩組的甲狀腺功能和甲狀腺體積。結(jié)果 治療后，對照組和治療組的總有效率分別為80.60%、94.03%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清游離三碘甲狀腺原氨酸（FT3）、游離四碘甲狀腺原氨酸（FT4）、甲狀腺過氧化物酶抗體（TPOAb）、甲狀腺球蛋白抗體（TGAb）水平均明顯下降，血清促甲狀腺激素（TSH）水平明顯上升，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些甲狀腺功能指標(biāo)的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組甲狀腺體積均明顯減小，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組甲狀腺體積明顯小于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 甲亢靈膠囊聯(lián)合丙硫氧嘧啶片治療Graves病具有較好的臨床療效，能明顯改善患者甲狀腺功能，減小甲狀腺體積，安全性較好，具有一定臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Jiakangling Capsules combined with Propylthiouracil Tablets in treatment of Graves disease. Methods Patients (134 cases) with Graves disease in Xi'an XD Group Hospital from February 2015 to January 2017 were randomly divided into control and treatment groups, and each group had 67 cases. Patients in the control group were po administered with Propylthiouracil Tablets, starting dosage 100 mg/time, three times daily, after the improvement of clinical symptoms and thyroid function, the dosage gradually reduced to 50-100 mg/d. Patients in the treatment group were po administered with Jiakangling Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and thyroid function and thyroid volume in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.60% and 94.03%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of FT3, FT4, TPOAb, and TGAb in two groups were significantly decreased, but the levels of TSH in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the thyroid function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the thyroid volumes in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the thyroid volumes in the treatment group were significantly smaller than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Jiakangling Capsules combined with Propylthiouracil Tablets has clinical curative effect in treatment of Graves disease, can significantly improve thyroid function, reduce thyroid volume, with good safety, which has a certain clinical application value.