目的 觀察注射用血栓通（凍干）聯(lián)合單唾液酸神經(jīng)節(jié)苷脂治療糖尿病周圍神經(jīng)病變的臨床療效。方法 選取2016年2月-2017年9月在湖北省中醫(yī)院就診的糖尿病周圍神經(jīng)病變患者64例，隨機(jī)分成對(duì)照組（31例）和治療組（33例）。對(duì)照組靜脈滴注單唾液酸四己糖神經(jīng)節(jié)苷脂鈉注射液，40 mg溶于250 mL生理鹽水，1次/d，連用2周，然后改為20 mg肌肉注射，維持2周。治療組在對(duì)照組基礎(chǔ)上靜脈滴注注射用血栓通（凍干），0.45 g溶于250 mL生理鹽水，1次/d，連用4周。觀察兩組患者臨床療效，比較治療前后兩組患者神經(jīng)傳導(dǎo)速度及血清NF-κB水平和多倫多臨床神經(jīng)病變?cè)u(píng)分（TCSS）。結(jié)果 治療后，對(duì)照組臨床總有效率為61.29%，顯著低于治療組的84.84%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組脛前神經(jīng)和腓總神經(jīng)的感覺神經(jīng)傳導(dǎo)速度（SNCV）傳導(dǎo)速度均顯著增加，治療組脛前神經(jīng)和腓總神經(jīng)的運(yùn)動(dòng)神經(jīng)傳導(dǎo)速度（MNCV）顯著增加，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組上述神經(jīng)傳導(dǎo)速度明顯快于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清NF-κB水平和TCSS均顯著降低，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組比對(duì)照組降低更明顯，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 注射用血栓通（凍干）聯(lián)合神經(jīng)節(jié)苷脂治療糖尿病周圍神經(jīng)病變具有較好的療效，可降低NF-κB水平，減輕患者神經(jīng)炎癥，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical effect of Xueshuantong for injection (freeze-dried) combined with monosialotetrahexosylganglioside in treatment of diabetic peripheral neuropathy. Methods Patients (64 cases) with diabetic peripheral neuropathy in Hubei Provincial Hospital of TCM from February 2016 to September 2017 were randomly divided into control (31 cases) and treatment (33 cases). Patients in the control group were iv administered with Monosialotetrahexosylganglioside Sodium Injection, 40 mg added into normal saline 250 mL, once daily for 2 weeks, then they were intramuscular injection with 20 mg for 2 weeks. Patients in the treatment group were iv administered with Xueshuantong for injection (freeze-dried) on the basis of the control group, 0.45 g added into normal saline 250 mL, once daily for 4 weeks. After treatment, the clinical efficacy was evaluated, and the nerve conduction velocity, the serum NF-κB level and TCSS in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 61.29%, which was significantly lower than 84.84% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the conduction velocity of SNCV of anterior tibial and common peroneal in two groups was significantly increased,and the conduction velocity of MNCV of anterior tibial and common peroneal in the treatment group was significantly increased, the difference was statistically significant in the same group (P < 0.05). And the nerve conduction velocity in the treatment group was significantly faster than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the NF-κB level and TCSS in two groups were significantly decreased, and there were differences in the same group (P < 0.05). And the indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Xueshuantong for injection (freeze-dried) combined with monosialotetrahexosylganglioside has good clinical effect in treatment of diabetic peripheral neuropathy, can reduce the NF-κB level and alleviate neuro inflammation, which has a certain clinical application value.

中國(guó)中醫(yī)科學(xué)院中醫(yī)基礎(chǔ)理論研究所“院所協(xié)同創(chuàng)新”科研專項(xiàng)基金資助項(xiàng)目（YZ-1748）