目的 探討皮膚病血毒片聯(lián)合鹽酸多西環(huán)素分散片治療痤瘡的臨床療效。方法 選取2017年2月-2017年7月在監(jiān)利縣人民醫(yī)院進(jìn)行診治的痤瘡患者78例臨床資料進(jìn)行回顧性分析，根據(jù)用藥的不同將所有患者分為對(duì)照組和治療組，每組各39例。對(duì)照組口服鹽酸多西環(huán)素分散片，1片/次，2次/d。治療組在對(duì)照組基礎(chǔ)上口服皮膚病血毒片，6片/次，2次/d。兩組均連續(xù)治療8周。觀察兩組的臨床療效，比較兩組的紅斑評(píng)分、色素沉著評(píng)分、皮損數(shù)量評(píng)分、痤瘡特異性生活質(zhì)量量表（Acne-QOL）評(píng)分、血清學(xué)指標(biāo)。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為79.49%、94.87%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組紅斑、色素沉著、皮損數(shù)量評(píng)分顯著下降，Acne-QOL評(píng)分顯著上升，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些評(píng)分指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-8（IL-8）、白細(xì)胞介素-17（IL-17）水平明顯降低，白細(xì)胞介素-10（IL-10）、干擾素-γ（IFN-γ）水平明顯升高，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些血清學(xué)指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 皮膚病血毒片聯(lián)合鹽酸多西環(huán)素分散片治療痤瘡具有較好的臨床療效，可促進(jìn)皮膚紅斑和色素沉著消退，改善皮損，調(diào)節(jié)機(jī)體炎癥反應(yīng)，提高生活質(zhì)量，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Pifubing Xuedu Tablets combined with Doxycycline Hyclate Dispersible Tablets in treatment of acne. Methods Patients (78 cases) with acne in Jianli County People's Hospital from February 2017 to July 2017 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 39 cases. Patients in the control group were po administered with Doxycycline Hyclate Dispersible Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Pifubing Xuedu Tablets on the basis of the control group, 6 tablets/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and erythema scores, pigmentation scores, skin lesion scores, Acne-QOL scores, and serological indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.49% and 94.87%, respectively, and there was difference between two groups (P < 0.05). After treatment, erythema scores, pigmentation scores, skin lesion scores in two groups were significantly decreased, but the Acne-QOL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the score indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α, IL-8, and IL-17 in two groups were significantly decreased, but the levels of IL-10 and IFN-γ in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the serological indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Pifubing Xuedu Tablets combined with Doxycycline Hyclate Dispersible Tablets has clinical curative effect in treatment of acne, can promote skin erythema and pigmentation subsiding, improve skin lesions, regulate the inflammatory response, and improve the quality of life, which has a certain clinical application value.