目的 探討腦血疏口服液聯(lián)合注射用單唾液酸四己糖神經(jīng)節(jié)苷脂鈉治療老年急性腦梗死的臨床療效。方法 選取2016年3月—2017年10月中國人民解放軍第二五四醫(yī)院收治的老年急性腦梗死患者92例為研究對象，按照隨機(jī)數(shù)字表法將所有患者分為對照組和治療組，每組各46例。對照組靜脈滴注注射用單唾液酸四己糖神經(jīng)節(jié)苷脂鈉，100 mg加入到生理鹽水100 mL，1次/d。治療組在對照組治療的基礎(chǔ)上口服腦血疏口服液，10 mL/次，3次/d。兩組均連續(xù)治療2周。觀察兩組的臨床療效，比較兩組的血清因子、神經(jīng)功能、日常生活能力。結(jié)果 治療后，對照組和治療組的總有效率分別為71.74%、89.13%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組丙二醛（MDA）、超敏C反應(yīng)蛋白（hs-CRP）、白細(xì)胞介素-6（IL-6）水平顯著降低，超氧化物歧化酶（SOD）水平明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組神經(jīng)元特異性烯醇化酶（NSE）、S-100β蛋白水平顯著降低，腦源性神經(jīng)營養(yǎng)因子（BDNF）、神經(jīng)生長因子（NGF）水平明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組美國國立衛(wèi)生研究院卒中量表（NIHSS）評分顯著降低，改良Barthel指數(shù)（MBI）評分明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 腦血疏口服液聯(lián)合注射用單唾液酸四己糖神經(jīng)節(jié)苷脂鈉治療老年急性腦梗死具有較好的臨床療效，可改善神經(jīng)功能和日常生活能力，減輕氧化應(yīng)激反應(yīng)及炎癥反應(yīng)，促進(jìn)腦神經(jīng)細(xì)胞恢復(fù)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the effect of Naoxueshu Oral Liquid combined with Monosialotetrahexosylganglioside Sodium for injection in treatment of acute cerebral infarction in the elderly. Methods Elderly patients (92 cases) with acute cerebral infarction in the No. 254 Hospital of PLA from March 2016 to October 2017 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were iv administered with Monosialotetrahexosylganglioside Sodium for injection, 100 mg added into normal saline 100 mL, once daily. Patients in the treatment group were po administered with Naoxueshu Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and serum factors, neurological function, and daily life ability in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.74% and 89.13%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of MDA, hs-CRP and IL-6 in two groups were significantly decreased, but the levels of SOD in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P< 0.05). After treatment, the levels of NSE and S-100β protein in two groups were significantly decreased, but the levels of BDNF and NGF in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the NIHSS scores in two groups were significantly decreased, but the MBI scores in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Naoxueshu Oral Liquid combined with Monosialote-trahexosylganglioside Sodium for injection has clinical curative effect in treatment of acute cerebral infarction in the elderly, can neurological function and daily life ability, relieve oxidative stress and inflammatory reaction, and promote recovery of brain neurons, which has a certain clinical application value.