目的 探討祛濁膠囊聯(lián)合阿托伐他汀鈣治療高脂血癥的臨床療效。方法 選取2015年7月—2017年7月在石家莊市第三醫(yī)院治療的高脂血癥患者108例，隨機(jī)分為對(duì)照組（54例）和治療組（54例）。對(duì)照組口服阿托伐他汀鈣片，20 mg/次，1次/d。治療組在對(duì)照組基礎(chǔ)上口服祛濁膠囊，3 g/次，3次/d。兩組患者均治療4周。觀察兩組患者臨床療效，比較治療前后兩組患者血脂水平、血清一氧化氮（NO）和內(nèi)皮素（ET）水平。結(jié)果 治療后，對(duì)照組和治療組臨床有效率分別為81.48%和96.30%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者三酰甘油（TG）、膽固醇（TC）和低密度脂蛋白膽固醇（LDL-C）顯著降低，高密度脂蛋白膽固醇（HDL-C）顯著升高，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者的血脂水平明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清NO水平顯著升高，ET水平顯著降低，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者NO和ET水平明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 祛濁膠囊聯(lián)合阿托伐他汀鈣治療高脂血癥效果顯著，可有效降低機(jī)體血脂水平，改善機(jī)體血管內(nèi)皮功能。

Objective To investigate the clinical efficacy of Quzhuo Capsules combined with atorvastatin calcium in treatment of hyperlipidemia. Methods Patients (108 cases) with hyperlipidemia in the Third Hospital of Shijiazhuang from July 2015 to July 2017 were randomly divided into control (54 cases) and treatment (54 cases). Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Quzhuo Capsules on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the blood lipid levels, the serum NO and ET levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.48% and 96.30% respectively, and there were differences between two groups (P < 0.05). After treatment, the TG, TC and LDL-C levels in two groups were significantly decreased, but the HDL-C levels were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the blood lipid levels in the treatment group after treatment were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the NO levels in two groups were significantly increased, but the ET levels were significantly decreased, and there were differences in the same group (P < 0.05). And the serum NO and ET levels in the treatment group after treatment were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Quzhuo Capsules combined with atorvastatin calcium has remarkable effect in treatment of hyperlipidemia, which can effectively reduce the blood lipid level and improve the vascular endothelial function.