目的 探討強(qiáng)骨膠囊聯(lián)合骨瓜提取物注射液治療骨質(zhì)疏松性股骨骨折的臨床效果。方法 選取2015年6月—2017年6月上海市浦東新區(qū)光明中醫(yī)院收治的98例骨質(zhì)疏松性股骨骨折患者，隨機(jī)分為對照組和治療組，每組各49例。對照組靜脈滴注骨瓜提取物注射液，100 mg加入250 mL生理鹽水均勻混合，1次/d，連續(xù)治療20 d為1個(gè)療程，停藥10 d；再按以上方案連用3個(gè)療程。治療組在對照組治療基礎(chǔ)上口服強(qiáng)骨膠囊，1粒/次，3次/d。兩組均連續(xù)治療3個(gè)月。觀察兩組的臨床療效，比較兩組治療1、3個(gè)月時(shí)骨痂骨密度（BMD）水平和骨愈合時(shí)間。比較兩組治療前后VAS評分、股骨頸BMD、HHS評分、鈣（Ca）、磷（P）、堿性磷酸酶（ALP）、骨鈣素（BGP）、24 h尿標(biāo)本中羥脯氨酸（HOP）水平的變化情況。結(jié)果 治療后，對照組和治療組的總有效率分別為79.59%、93.88%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組治療1、3個(gè)月時(shí)骨痂BMD值顯著高于對照組治療同期，治療組骨折愈合時(shí)間顯著短于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組VAS評分、Ca、ALP水平和24 h尿HOP顯著降低，股骨頸BMD、HHS評分、P、BGP顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組VAS評分、Ca、ALP水平和24 h尿HOP低于對照組，股骨頸BMD、HHS評分、P、BGP顯著高于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 強(qiáng)骨膠囊聯(lián)合骨瓜提取物注射液治療骨質(zhì)疏松性股骨骨折具有較好的臨床療效，可有效減輕患者疼痛，增加骨密度，促進(jìn)骨折愈合，調(diào)控骨代謝平衡，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Qianggu Capsules combined with Gugua Extract Injection in treatment of osteoporotic femoral fracture. Methods Patients (98 cases) with osteoporotic femoral fracture in Guangming Chinese Medicine Hospital of Pudong New Area Shanghai from June 2015 to June 2017 were randomly divided into control (49 cases) and treatment (49 cases) groups. Patients in the control group were iv administered with Gugua Extract Injection, 100 mg added into 250 mL normal saline, once daily, 20 d for one course of treatment, discontinuation of 10 d. Follow the above scheme for three courses. Patients in the treatment group were po administered with Qianggu Capsules on the basis of the control group. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the osteotylus BMD in 1 and 3 months of the treatment and bone healing time in two groups were compared. The changes of VAS score, femoral neck BMD, HHS score, Ca, P, ALP, BGP, and 24 h HOP in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 79.59% and 93.88%, and there were differences between two groups (P < 0.05). After treatment, the osteotylus BMD in 1 and 3 months of the treatment in the treatment group were higher than those in the control group, and bone healing time in the treatment group was shorter than that in the control group, and there were differences between two groups (P < 0.05). After treatment, VAS score, Ca, ALP, and 24 h HOP in two groups were significantly decreased, but femoral neck BMD, HHS score, P, and BGP were significantly increased, and there were differences in the same group (P < 0.05). After treatment, VAS score, Ca, ALP, and 24 h HOP in the treatment group were lower than those in the control group, but femoral neck BMD, HHS score, P, and BGP were higher than those in the control group, there were differences between two groups (P < 0.05). Conclusion Qianggu Capsules combined with Gugua Extract Injection has significant clinical effect in treatment of osteoporotic femoral fracture, and can relieve pain effectively, increase bone mineral density, also can promote fracture healing and regulate bone metabolism balance, which has a certain clinical application value.