目的 探討貞芪扶正膠囊聯(lián)合枸櫞酸他莫昔芬片治療雌激素受體陽性乳腺癌的臨床療效。方法 選取2016年1月—2017年7月河南科技大學第一附屬醫(yī)院收治的雌激素受體陽性乳腺癌患者86例為研究對象，按照隨機數(shù)字表法將所有患者分為對照組和治療組，每組各43例。對照組口服枸櫞酸他莫昔芬片，10 mg/次，2次/d。治療組在對照組基礎(chǔ)上口服貞芪扶正膠囊，6粒/次，2次/d。兩組患者均連續(xù)治療12周。觀察兩組的臨床療效，比較兩組的淋巴細胞、NK細胞和不良反應(yīng)。結(jié)果 治療后，對照組和治療組的有效率分別為32.56%、48.84%，兩組有效率比較無明顯差異。治療后，對照組和治療組的控制率分別為51.16%、72.09%，兩組控制率比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組CD³⁺、CD⁴⁺、CD⁴⁺/CD⁸⁺、NK細胞水平均顯著升高（P<0.05），同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標明顯高于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療組不良反應(yīng)中惡心、頭痛和潮熱例數(shù)較對照組少，兩組比較差異有統(tǒng)計學意義（P<0.05）。結(jié)論 貞芪扶正膠囊聯(lián)合枸櫞酸他莫昔芬片治療雌激素受體陽性乳腺癌具有較好的臨床療效，能改善免疫系統(tǒng)功能，安全性較好，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Zhenqi Fuzheng Capsules combined with Tamoxifen Citrate Tablet in treatment of estrogen receptor positive breast cancer. Methods Patients (86 cases) with estrogen receptor positive breast cancer in the First Affiliated Hospital of Henan University of Science and Technology from January 2016 to February 2017 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Tamoxifen Citrate Tablets, 10 mg/time, twice daily. Patients in the treatment group were po administered with Zhenqi Fuzheng Capsules on the basis of the control group, 6 grains/time, twice daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and lymphocytes, NK cells, and adverse reaction in two groups were compared. Results After treatment, the clinical efficacies rates in the control and treatment groups were 32.56% and 48.84%, respectively, and there was no difference between two groups. After treatment, the control rates in the control and treatment groups were 51.16% and 72.09%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of CD³⁺, CD⁴⁺, CD⁴⁺/CD⁸⁺, and NK cells in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). The incidence of nausea, headache, and hot flashes in two groups were difference between two groups (P < 0.05). Conclusion Zhenqi Fuzheng Capsules combined with Tamoxifen Citrate Tablets has clinical curative effect in treatment of estrogen receptor positive breast cancer, can improve immune system function, with good safety, which has a certain clinical application value.