目的 探討異甘草酸鎂聯(lián)合左西替利嗪治療濕疹的臨床效果。方法 選取2016年1月—2017年12月天津市寧河區(qū)醫(yī)院收治的142例濕疹患者，隨機(jī)分為對(duì)照組和治療組，每組各71例。對(duì)照組患者口服鹽酸左西替利嗪片，5 mg/d，每晚睡前頓服。治療組在對(duì)照組的基礎(chǔ)上靜脈滴注異甘草酸鎂注射液，0.1 g加入10%葡萄糖注射液250 mL中，1次/d。兩組均連續(xù)治療2周。觀察兩組的臨床療效，比較兩組的癥狀體征評(píng)分、血清細(xì)胞因子和外周血指標(biāo)和皮膚病生活質(zhì)量指數(shù)（DLQI）評(píng)分。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為74.6%、90.1%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組臨床癥狀、皮損面積、嚴(yán)重度指數(shù)（EASI）及瘙癢程度評(píng)分均較治療前顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.01）；且治療后治療組上述癥狀體征評(píng)分顯著低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.01）。兩組血清干擾素-γ（INF-γ）、白細(xì)胞介素（IL）-4濃度均顯著降低，外周血輔助性T細(xì)胞1和2比率（Th1/Th2）、CD⁴⁺和CD⁸⁺ T細(xì)胞比值（CD⁴⁺/CD⁸⁺）均顯著增加，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05、0.01）；且治療組上述指標(biāo)顯著優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組DLQI總分較治療前均顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.01）；且治療后治療組DLQI總分顯著低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.01）。結(jié)論 異甘草酸鎂聯(lián)合左西替利嗪治療濕疹具有較好的臨床療效，可改善癥狀體征，抑制炎性反應(yīng)，調(diào)控免疫狀態(tài)，提高生活質(zhì)量，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of magnesium isoglycyrrhizinate combined with levocetirizine in treatment of eczema. Methods Patients (142 cases) with eczema in Tianjin Ninghe District Hospital from January 2016 to December 2017 were divided into control and treatment groups, and each group had 71 cases. Patients in the control group were po administered with Levocetirizine Hydrochloride Tablets before going to bed, 5 mg/d. Patients in the treatment group were iv administered with Magnesium Isoglycyrrhizinate Injection, 0.1 g added into 10% glucose injection 250 mL, once daily, and they were treated for 2 week. After treatment, the clinical efficacy was evaluated, and symptoms and signs score, serum cell factor and peripheral blood index, and DLQI in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.6% and 90.1%, respectively, and there was difference between two groups (P < 0.05). Symptoms and signs score, psoriasis area, EASI, and itching degree score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.01). And the symptoms and signs score in the treatment group was significantly lower than those in the control group, with significant difference between two groups (P < 0.05). INF-γ and IL-4 in two groups were significantly decreased, but Th1/Th2 and CD⁴⁺/CD⁸⁺ in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05, 0.01). And the indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). DLQI total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.01). And the DLQI total score in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.01). Conclusion Magnesium isoglycyrrhizinate combined with levocetirizine has good effect in treatment of eczema, can rapidly improve the symptoms and signs, inhibit the inflammatory reaction, regulate the immune status and improve the quality of life, which has a certain clinical application value.