目的 調(diào)查2012—2016年烏魯木齊市第四人民醫(yī)院抗抑郁藥物的應(yīng)用情況以及變化趨勢，為抗抑郁藥物的合理使用提供參考依據(jù)。方法 按照藥品類型和品規(guī)對2012—2016年烏魯木齊市第四人民醫(yī)院抗抑郁藥物進行統(tǒng)計，并對具體藥物的銷售金額、用藥頻度（DDDs）、日均費用（DDC）和藥品排序比（B/A）值進行分析。結(jié)果 2012—2016年，抗抑郁藥物的銷售金額呈上升趨勢，構(gòu)成比基本穩(wěn)定。門診和住院部就診人數(shù)以及抗抑郁癥藥物的銷售金額均呈增長趨勢。除鹽酸氯米帕明片以外，其余抗抑郁藥物的銷售金額和DDDs均逐年上升，銷售金額最高的為鹽酸文拉法辛緩釋膠囊，鹽酸帕羅西汀片的DDDs自2013年以來一直位于第1位，其B/A值較高，其余各藥物的B/A值接近于1.00。各藥物的DDC值基本穩(wěn)定，鹽酸曲唑酮片引入本院后，其DDC值一直位于第1位。結(jié)論 烏魯木齊市第四人民醫(yī)院抗抑郁藥物的臨床使用合理，符合現(xiàn)代臨床用藥的發(fā)展趨勢，安全、有效、副作用小的藥物越來越受到歡迎。

Objective To investigate the clinical application and variation trend of antidepressants in Urumqi Fourth People's Hospital from 2012 to 2016, so as to provide a reference for the rational use of antidepressants. Methods Antidepressants were collected by the drug types and categories, and the sale amounts, defined daily dose system (DDDs), defined daily cost (DDC) and B/A were then analyzed statistically. Results From 2012 to 2016, sale amounts of antidepressants were increased year by year, and the constituent was basically stable. Also, the usage of antidepressants in outpatient and inpatient showed an increasing trend year by year. Sale amounts and DDDs of other antidepressants were gradually increased except Clomipramine Hydrochloride Tablets. Sale amounts of Venlafaxine Hydrocloride Sustained-release Capsules was the highest. DDDs of Paroxetine Hydrochloride Tablets ranked the first since 2013. And Paroxetine Hydrochloride Tablets had higher B/A value. B/A values of other antidepressants were close to 1.00. DDC of all antidepressants were stable. DDC of Paroxetine Hydrochloride Tablets ranked the first since it was introduced to the hospital. Conclusion The utilization of antidepressant drugs in Urumqi Fourth People's Hospital is reasonable. This phenomenon conforms to the development trend of clinic treatment. Safe and effective drugs with minimal side effect are becoming more and more popular.