目的 探討應(yīng)用丹紅注射液聯(lián)合多奈哌齊治療阿爾茨海默病的臨床效果。方法 選取2015年6月-2017年6月中國(guó)人民解放軍白求恩國(guó)際和平醫(yī)院收治的阿爾茨海默病患者106例，隨機(jī)分成對(duì)照組（53例）與治療組（53例）。對(duì)照組睡前口服鹽酸多奈哌齊片，5 mg/次，1次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注丹紅注射液，40 mL加入250 mL生理鹽水，1次/d。兩組均連續(xù)治療4周。評(píng)價(jià)兩組患者臨床療效，同時(shí)比較治療前后兩組患者簡(jiǎn)易精神狀態(tài)量表（MMSE）評(píng)分、腦血流動(dòng)力學(xué)和血清學(xué)指標(biāo)。結(jié)果 治療后，對(duì)照組臨床有效率為77.4%，顯著低于治療組的92.5%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組MMSE評(píng)分較治療前均顯著增加（P<0.05）；且治療組比對(duì)照組升高更顯著（P<0.05）。治療后，治療組基底動(dòng)脈（BA）和雙側(cè)大腦中動(dòng)脈（MCA）的平均血流速度（MFV）值均顯著升高（P<0.05），搏動(dòng)指數(shù)（PI）值顯著下降（P<0.05）；且治療后治療組BA和雙側(cè)MCA的MFV值和PI值比對(duì)照組改善更顯著（P<0.05）。治療后，兩組血清血清磷酸化tau蛋白（P-tau）、丙二醛（MDA）、白細(xì)胞介素（IL）-8和超敏C反應(yīng)蛋白（hs-CRP）水平較治療前均顯著降低（P<0.05），超氧化物歧化酶（SOD）水平均顯著增加（P<0.05）；且治療組上述血清學(xué)指標(biāo)比對(duì)照組改善更顯著（P<0.05）。結(jié)論 應(yīng)用丹紅注射液聯(lián)合多奈哌齊治療阿爾茨海默病可有效改善患者腦血流狀態(tài)，減輕機(jī)體氧化應(yīng)激與炎癥損傷，提高認(rèn)知功能，延緩病情進(jìn)展。

Objective To investigate the clinical effect of Danhong Injection combined with donepezil in treatment of Alzheimer disease. Methods Patients (106 cases) with Alzheimer disease in Bethune International Peace Hospital of PLA. from June 2015 to June 2017 were randomly divided into control (53 cases) and treatment (53 cases) group. Patients in the control group were po administered with Donepezil Hydrochloride Tablets, 5 mg/time, once daily. Patients in the treatment group were iv administered with Danhong Injection on the basis of the control group, 40 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clincial efficacies were evaluated, and the MMSE scores, the cerebral hemodynamics, the serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 77.4%, which was significantly lower than 92.5% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the MMSE scores in two groups were significantly increased (P<0.05), and the scores in the treatment group after treatment were significantly higher than that in the control group (P<0.05). After treatment, the BA, MFV value in two groups was significantly increased (P<0.05), but PI was significantly decreased (P<0.05). And the BA, MFV and PI value in the treatment group after treatment was significantly better than that in the control group (P<0.05). After treatment, the P-tau, MDA, IL-8 and hs-CRP levels in two groups were significantly decreased (P<0.05), but SOD levels were significantly increased (P<0.05). And the serological indexes in the treatment group after treatment was significantly better than that in the control group (P<0.05). Conclusion Danhong Injection combined with donepezil in treatment of Alzheimer disease can effectively improve the cerebral blood flow, reduce oxidative stress and inflammatory injury, improve cognitive function, and delay the disease progress.