目的 探討橘紅痰咳液聯(lián)合乙酰半胱氨酸治療慢性阻塞性肺疾病（COPD）患者的臨床療效。方法 選取2016年10月-2017年10月在濮陽市安陽地區(qū)醫(yī)院進(jìn)行治療的COPD患者82例，隨機(jī)將患者分為對照組（41例）和治療組（41例）。對照組口服溶解后的乙酰半胱氨酸泡騰片，0.6 mg/次，2次/d；治療組在對照組基礎(chǔ)上口服橘紅痰咳液，20 mL/次，3次/d。兩組患者均經(jīng)過12周治療。評價兩組患者臨床療效，同時比較治療前后兩組患者動脈血?dú)夥治鲋笜?biāo)、肺功能指標(biāo)、血清細(xì)胞因子水平和氧化應(yīng)激水平。結(jié)果 治療后，對照組臨床有效率為80.49%，顯著低于治療組的95.12%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組氧分壓（pO₂）和血氧飽和度（SaO₂）水平及一秒用力呼氣容積（FEV₁）、用力肺活量（FVC）和最大呼氣流量（PEF）均顯著升高（P<0.05），二氧化碳分壓（pCO2）水平顯著下降（P<0.05），且治療組上述動脈血?dú)夂头喂δ苤笜?biāo)改善后水平明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組血清IL-6、髓樣細(xì)胞觸發(fā)受體-1（sTREM-1）、單核細(xì)胞趨化因子-1（MCP-1）和丙二醛（MDA）水平均顯著降低（P<0.05），γ-干擾素（IFN-γ）、超氧化物歧化酶（SOD）和谷胱甘肽過氧化物酶（GPX）水平顯著增加（P<0.05）。同時，治療后治療組上述血清細(xì)胞因子和氧化應(yīng)激水平明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 橘紅痰咳液聯(lián)合乙酰半胱氨酸治療COPD，有利于患者肺功能和動脈血?dú)庵笜?biāo)改善，并降低機(jī)體炎癥和氧化應(yīng)激水平。

Objective To evaluate the clinical efficacy of Juhong Tanke Liquid combined with acetylcysteine in treatment of chronic obstructive pulmonary disease. Methods Patients (82 cases) with chronic obstructive pulmonary disease in Anyang District Hospital from October 2016 to October 2017 were randomly divided into control (41 cases) and treatment (41 cases) groups. Patients in the control group were po administered with Acetylcysteine Effervescent Tablets dissolved in water, 0.6 mg/time, twice daily. Patients in the treatment group were po administered with Juhong Tanke Liquid on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the arterial blood gas indexes, the pulmonary function, the serum cytokine levels, the levels of oxidative stress in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.49%, which was significantly lower than 95.12% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the pO₂, SaO₂, FEV₁, FVC, and PEF levels in two groups were significantly increased (P<0.05), but the pCO2 levels were significantly decreased (P<0.05), at the same time the arterial blood gas and pulmonary function indexes in the treatment group after treatment were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the serum IL-6, sTREM-1, MCP-1 and MDA levels in two groups were significantly decreased (P<0.05), but IFN-γ, SOD and GPX levels were significantly increased (P<0.05), at the same time, the serum cytokine levels and the levels of oxidative stress in the treatment group after treatment were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Juhong Tanke Liquid combined with acetylcysteine in treatment of chronic obstructive pulmonary disease can effectively improve the pulmonary function and arterial blood gas, reduce the inflammatory reaction and oxidative stress level.