目的 研究養(yǎng)胃舒膠囊聯(lián)合奧美拉唑腸溶膠囊治療慢性胃炎的臨床療效。方法 選取2015年6月-2017年6月寧夏醫(yī)科大學總醫(yī)院收治的慢性胃炎患者120例為研究對象，將所有患者隨機分為對照組和治療組，每組各60例。對照組患者口服奧美拉唑腸溶膠囊，1粒/次，1次/d。治療組在對照組的基礎上口服養(yǎng)胃舒膠囊，3粒/次，2次/d。兩組患者均連續(xù)治療8周。觀察兩組的臨床療效，比較兩組的血清炎癥因子、氧化應激因子水平。結果 治療后，對照組和治療組的總有效率分別為85.00%、95.00%，兩組比較差異有統(tǒng)計學意義（P<0.05）。兩組血清白細胞介素-8（IL-8）、白細胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）水平均顯著升高，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組血清炎癥因子水平明顯高于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患者超氧化物歧化酶（SOD）、一氧化氮（NO）水平顯著升高，丙二醛（MDA）水平顯著下降，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組血清氧化應激因子水平明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 養(yǎng)胃舒膠囊聯(lián)合奧美拉唑腸溶膠囊治療慢性胃炎具有較好的臨床療效，可調(diào)節(jié)炎性因子和氧化應激因子水平，安全性較好，具有一定臨床推廣應用價值。

Objective To study the clinical effect of Yangweishu Capsules combined with Omeprazole Enteric-coated Capsules in treatment of chronic gastritis. Methods Patients (120 cases) with chronic gastritis in General Hospital of Ningxia Medical University from June 2015 to June 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Omeprazole Enteric-coated Capsules, 1 grain/time, once daily. Patients in the treatment group were po administered with Yangweishu Capsules on the basis of the control group, 3 grains/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the serum levels of inflammatory factors and oxidative stress factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.00% and 95.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of IL-8, IL-6, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of SOD and NO in two groups were significantly increased, but the levels of MDA in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Yangweishu Capsules combined with Omeprazole Enteric-coated Capsules has clinical curative effect in treatment of chronic gastritis, can regulate the levels of inflammatory factor and oxidative stress factor, with good safety, which has a certain clinical application value.