目的 研究胰膽炎合劑聯(lián)合注射用烏司他丁治療急性胰腺炎的臨床療效。方法 選取2017年1月-2017年12月西安交通大學(xué)第一附屬醫(yī)院收治的急性胰腺炎患者120例為研究對(duì)象，所有患者隨機(jī)分為對(duì)照組和治療組，每組各60例。對(duì)照組靜脈滴注注射用烏司他丁，10萬單位加入到0.9%氯化鈉注射液500 mL中，靜滴時(shí)間2 h，1次/d。治療組在對(duì)照組治療的基礎(chǔ)上口服胰膽炎合劑，1袋/次，2次/d。兩組患者持續(xù)治療7 d。觀察兩組的臨床療效，比較兩組的臨床癥狀恢復(fù)時(shí)間和生化指標(biāo)水平。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為85.00%、96.67%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組腹痛緩解時(shí)間、胃腸功能恢復(fù)時(shí)間、血尿淀粉酶正常時(shí)間、白細(xì)胞計(jì)數(shù)恢復(fù)時(shí)間均顯著短于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組C反應(yīng)蛋白（CRP）、白細(xì)胞（WBC）、淀粉酶（AMY）和乳酸脫氫酶（LDH）水平均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組生化指標(biāo)水平明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 胰膽炎合劑聯(lián)合注射用烏司他丁治療急性胰腺炎具有較好的臨床療效，能改善患者臨床癥狀，調(diào)節(jié)CRP、WBC、AMY和LDH水平，安全性較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To study the clinical effect of Yidanyan Mixture combined with Ulinastatin for injection in treatment of acute pancreatitis. Methods Patients (120 cases) with acute pancreatitis in the First Affiliated Hospital of Xi'an Jiaotong University from January 2017 to December 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were iv administered with Ulinastatin for injection, 100 000 unit added into normal saline 500 mL, drop time 2 h, twice daily. Patients in the treatment group were po administered with Yidanyan Mixture on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the recovery times of clinical symptoms and the levels of biochemical indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.00% and 96.67%, respectively, and there was difference between two groups (P<0.05). After treatment, abdominal pain relief time, gastrointestinal function recovery time, blood urine amylase normal time, and white blood cell count recovery time in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of CRP, WBC, AMY, and LDH in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the biochemical indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Yidanyan Mixture combined with Ulinastatin for injection has clinical curative effect in treatment of acute pancreatitis, can improve the clinical symptoms of patients, and regulate the levels of CRP, WBC, AMY, and LDH, with good safety, which has a certain clinical application value.