目的 探討龍血竭散灌腸聯(lián)合柳氮磺吡啶腸溶片治療潰瘍性結(jié)腸炎的臨床療效。方法 選取2015年9月-2017年10月在上海市松江區(qū)方塔中醫(yī)醫(yī)院接受治療的潰瘍性結(jié)腸炎患者105例為研究對象，根據(jù)用藥方法不同將患者分為對照組（51例）和治療組（54例）。對照組口服柳氮磺吡啶腸溶片，1.0 g/次，3次/d。治療組在對照組治療的基礎(chǔ)上灌腸龍血竭散，1.2 g加入到生理鹽水100 mL中，腸道保留時(shí)間1 h，1次/d。10 d為1個(gè)療程，所有患者均接受4個(gè)療程治療，療程間隔時(shí)間為5 d。觀察兩組的臨床療效，比較兩組的促炎性因子水平、Sutherland指數(shù)和Baron內(nèi)鏡評分。結(jié)果 治療后，對照組和治療組的內(nèi)鏡療效總有效率分別為76.5%、90.7%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對照組和治療組的臨床療效總有效率分別為82.4%、94.4%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清腫瘤壞死因子-α（TNF-α）、C反應(yīng)蛋白（CRP）、白細(xì)胞介素-1β（IL-1β）、白細(xì)胞介素-8（IL-8）水平均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些促炎性因子水平明顯低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組Sutherland指數(shù)和Baron內(nèi)鏡評分均明顯下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 龍血竭散灌腸聯(lián)合柳氮磺吡啶腸溶片治療潰瘍性結(jié)腸炎具有較好的臨床療效，可改善臨床癥狀，降低促炎性因子水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Longxuejie Powder enema combined with Sulfasalazine Enteric-coated Tablets in treatment of ulcerative colitis. Methods Patients (105 cases) with ulcerative colitis in Songjiang District Fangta Traditional Chinese Medicine Hospital of Shanghai from September 2015 to October 2017 were randomly divided into the control group (51 cases) and the treatment group (54 cases) according to method. Patients in the control group were po administered with Sulfasalazine Enteric-coated Tablets, 1.0 g/time, three times daily. Patients in the treatment group were enema administered with Longxuejie Powder on the basis of the control group, 1.2 g added into normal saline 100 mL, intestinal retention time for 1 h, once daily. 10 d for 1 course, patients in two groups were treated for 4 courses with treatment interval of 5 d. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and proinflammatory factor levels, Sutherland index scores, and Baron endoscopy scores in two groups were compared. Results After treatment, the endoscopic efficacies in the control and treatment groups were 76.5% and 90.7%, respectively, and there was difference between two groups (P<0.05). After treatment, the clinical efficacies in the control and treatment groups were 82.4% and 94.4%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of TNF-α, CRP, IL-1β, and IL-8 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the proinflammatory factor levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, Sutherland index scores and Baron endoscopy scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Longxuejie Powder enema combined with Sulfasalazine Enteric-coated Tablets has clinical curative effect in treatment of ulcerative colitis, can improve clinical symptoms, decrease proinflammatory factor levels, which has a certain clinical application value.