目的 探討左歸丸聯(lián)合鮭魚降鈣素治療老年骨質(zhì)疏松癥的臨床效果。方法 選取2016年1月-2017年6月安陽(yáng)市第六人民醫(yī)院收治的126例老年骨質(zhì)疏松癥患者，隨機(jī)分為對(duì)照組和治療組，每組各63例。對(duì)照組肌肉注射注射用鮭魚降鈣素，50 U/次，1次/d。治療組在對(duì)照組治療基礎(chǔ)上口服左歸丸，9 g/次，2次/d。兩組均連續(xù)治療3個(gè)月。觀察兩組的臨床療效，比較兩組治療前后兩組患者癥狀積分、不同部位骨密度（BMD）、腫瘤壞死因子（TNF）-α、骨堿性磷酸酶（BALP）、酸性磷酸酶（TRACP）、尿脫氧吡啶啉排泄率（D-Pyr/Cr）的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為80.95%、93.65%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組各項(xiàng)癥狀積分、總分、TNF-α、BALP、TRACP、尿中D-Pyr/Cr值均顯著降低，跟骨、Ward三角區(qū)、全髖骨、腰椎L_2-4的BMD值較治療前均顯著增高，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組各項(xiàng)癥狀積分、總分、TNF-α、BALP、TRACP、尿中D-Pyr/Cr值均顯著低于對(duì)照組，跟骨、Ward三角區(qū)、全髖骨、腰椎L_2-4的BMD值較治療前均顯著增高，高于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 左歸丸聯(lián)合鮭魚降鈣素治療老年骨質(zhì)疏松癥具有較好的臨床療效，可明顯減輕患者的臨床癥狀，增加骨密度，調(diào)控骨代謝平衡，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effects of Zuogui Pills combined with salmon calcitonin in treatment of senile osteoporosis. Methods Patients (126 cases) with senile osteoporosis in Anyang People's Hospital No.6 from January 2016 to June 2017 were randomly divided into control (63 cases) and treatment (63 cases) groups. Patients in the control group were im administered with Salcatonin for injection, 50 U/time, once daily. Patients in the treatment group were po administered with Zuogui Pills on the basis of the control group, 9 g/time, twice dialy. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the changes of symptoms integral, BMD of different parts, TNF-α, BALP, TRACP, and D-Pyr/Cr of urine in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group were 80.95% and 93.65%, and there were differences between two groups (P<0.05). After treatment, symptoms integrals, total integral, TNF-α, BALP, TRACP, and D-Pyr/Cr of urine in two groups were significantly decreased, but BMD of calcaneal, ward triangle, total hip, and lumbar 2-4 were significantly increased, and there were differences in the same group (P<0.05). After treatment, symptoms integrals, total integral, TNF-α, BALP, TRACP, and D-Pyr/Cr of urine in the treatment group were lower than those in the control group, but BMD of calcaneal, ward triangle, total hip, and lumbar 2-4 were higher than those in the control group, and there were differences between two groups (P<0.05). Conclusion Zuogui Pills combined with salmon calcitonin has significant clinical effect in treatment of senile osteoporosis, and can significantly reduce clinical symptoms, and can increase bone density and regulate bone metabolism balance, which has a certain clinical application value.