目的 分析華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院腫瘤中心抗菌藥物的使用情況，為腫瘤患者使用抗菌藥物的質(zhì)量控制提供參考依據(jù)。方法 對華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院腫瘤中心2015年1月-2017年12月抗菌藥物的用藥品種、銷售金額、用藥頻度（DDDs）、日均藥費(fèi)（DDC）和排序比（B/A）等進(jìn)行統(tǒng)計(jì)分析。結(jié)果 2015-2017年抗菌藥物的銷售金額占總藥品金額的比例分別為5.23%、4.67%、4.33%；頭孢菌素類的銷售金額和DDDs排名連續(xù)3年位居第1位，碳青霉烯類、糖肽類、唑酮類的銷售金額、DDDs較前兩年有明顯的增長；青霉素類、頭孢菌素類、喹諾酮類及和抗真菌藥品B/A均為1.00，氨基苷類、硝咪唑類的B/A均大于1.00，β-內(nèi)酰胺類復(fù)方制劑、碳青霉烯類、糖肽類、唑酮類的B/A均小于1.00；DDDs排名前15名的抗菌藥物3年來每種藥物的DDC都在逐年降低。結(jié)論 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院腫瘤中心抗菌藥物的使用日趨合理，但患者的經(jīng)濟(jì)負(fù)擔(dān)較重，應(yīng)進(jìn)一步加強(qiáng)管理。

Objective To investigate the use of antibiotics in Tumor Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and to provide reference for the quality control of antibiotics used in cancer patients. Methods The drug category, consumption sums, defined daily dose system (DDDs), average daily cost (DDC) and B/A values of antibiotics from January 2015 to December 2017 in Tumor Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology were analyzed statistically. Results The consumption amount of antibacterial drugs accounted for 5.23%, 4.67%, and 4.33% from 2015 to 2017. Consumption sums and DDDs of cephalosporins ranked the first in three consecutive years. Consumption sums and DDDs of the antibiotics, including carbapenenes, glycopeptides and oxazolone, were significantly increased compared with those of the previous two years. B/A of penicillin, cephalosporin, quinolone, and antifungal drugs were all 1.00. B/A of aminoglycoside and nitroimidazoles were above 1.00 in 3 years. B/A of glycopeptide, oxazolone, carbapenem, β-lactamase antibiotics were less than 1.00. DDC of antibacterial drugs with top 15 DDDs had been decreasing year by year in the past 3 years. Conclusion The use of antimicrobial agents in Tumor Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology is becoming more and more reasonable. But the patients' financial burden is still heavy, therefore, further management should be strengthened.