目的 分析六安市人民醫(yī)院抗感染藥物不良反應(yīng)/事件的規(guī)律及特點(diǎn)，為臨床合理應(yīng)用提供參考。方法 搜集2008年1月-2017年12月六安市人民醫(yī)院上報(bào)至國家藥品不良反應(yīng)監(jiān)測(cè)系統(tǒng)的543例抗感染藥物不良反應(yīng)/事件報(bào)告，利用回顧性分析手段對(duì)患者基本情況、抗感染藥物分類、不良反應(yīng)臨床表現(xiàn)、給藥途徑等多方面進(jìn)行分析、研究。結(jié)果 543例抗感染藥物不良反應(yīng)/事件報(bào)告中，男、女患者分別為271、272例；大于65歲年齡段發(fā)生率最高，占23.94%；共涉及12大類56種抗感染藥物，其中不良反應(yīng)例數(shù)最多的是頭孢菌素類（218例，40.15%），其次是喹諾酮類（81例，14.92%）；累及的器官或系統(tǒng)主要是皮膚及其附件（231例，42.54%），其次是消化系統(tǒng)（173例，31.86%）；給藥途徑主要是靜脈滴注（313例，57.64%），其次是口服（213例，39.23%）。結(jié)論 六安市人民醫(yī)院抗感染藥物不良反應(yīng)/事件的發(fā)生與藥物種類，給藥途徑等多種因素有關(guān)，醫(yī)療機(jī)構(gòu)應(yīng)重視抗感染藥物不良反應(yīng)，加強(qiáng)抗感染藥物的臨床應(yīng)用監(jiān)管。

Objective To analyze the laws and characteristics of adverse anti-infection drugs reactions/events, and provide references for the promotion of rational clinical application. Methods 543 Cases of effective anti-infection drugs adverse reaction reports from January 2008 and December 2017 in Lu'an People's Hospital to National ADR Monitoring Center were selected and analyzed according to the patient's basic situation, anti-infection drugs classification, clinical manifestations of adverse reactions, and route of administration. Results In 543 cases of adverse drug reaction/incident report, 271 cases of men and 272 cases of women were reported. Patients over the age of 65 had the highest incidences (23.94%). There were 12 categories of 56 anti-infective agents, among which the most adverse reactions were cephalosporin (218 cases, 40.15%), followed by quinolones (81 cases, 14.92%). The organs or systems involved were mainly skin and accessories (231 cases, 42.54%), followed by the digestive system (173 cases, 31.86%). The main route of administration was intravenous drip (313 cases, 57.64%), followed by oral (213 cases, 39.23%). Conclusion The adverse reaction of anti-infection drug in Lu'an People's Hospital is related to many factors such as drug types and route of administration. Medical institutions should pay attention to the adverse reaction of anti-infection drug and strengthen the clinical application supervision.

六安市公立醫(yī)院中央財(cái)政醫(yī)改項(xiàng)目