目的 探討頭孢地嗪致不良反應(yīng)發(fā)生的規(guī)律和特點(diǎn)，為臨床合理用藥提供參考。方法 檢索從建庫至2018年2月Pubmed、中國學(xué)術(shù)期刊（網(wǎng)絡(luò)版）、萬方數(shù)字化期刊全文庫、中文科技期刊全文數(shù)據(jù)庫（維普）中關(guān)于頭孢地嗪不良反應(yīng)的個案報道，并進(jìn)行統(tǒng)計(jì)和分析。結(jié)果 共檢索到24篇文獻(xiàn)，33例病例。年齡集中在0~18歲和60歲以上。給藥方式主要為靜脈滴注。原患疾病主要以呼吸系統(tǒng)感染為主。不良反應(yīng)大多發(fā)生于用藥30 min內(nèi)，構(gòu)成比為42.42%。頭孢地嗪引發(fā)的不良反應(yīng)主要涉及全身性損害、消化系統(tǒng)損害、皮膚及附件損害、呼吸系統(tǒng)損害、心血管系統(tǒng)損害和中樞神經(jīng)系統(tǒng)損害，全身性損害例數(shù)最多，臨床表現(xiàn)主要為過敏性樣反應(yīng)和過敏性休克。結(jié)論 臨床應(yīng)重視頭孢地嗪不良反應(yīng)的危害性，加強(qiáng)藥學(xué)監(jiān)護(hù)，盡量避免或減少其所致不良反應(yīng)的發(fā)生，確保患者用藥安全。

Objective To investigate the regularities and characteristics of adverse reactions caused by cefodizime, and to provide a reference for clinical rational drug use. Methods PubMed databases, Chinese Academic Journal (online), Wangfang Database, Chinese Science, and Technology Journal Full-text Database (VIP) were retrieved from building database to February 2018, and the documents of ADR induced by cefodizime were analyzed and discussed. Results A total of 24 literatures with 33 patients were retrieved. The ages of patients were mainly 0-18 years old and above 60 years old. The main method of administration was intravenous drip. The primary disease was mainly respiratory infection. The most cases occured in the medication in 30 min, accounting for 42.42%. ADR induced by cefodizime mainly occured in systemic damage, digestive system hurt, skin and accessory damage, cardiovascular system damage, and nervous system damage, in which systemic damage took the most ratios. And the main clinical manifestation were anaphylaxis and allergic shock. Conclusion Importance should be attached to the danger of ADR induced by cefodizime and pharmaceutical care should be strengthened, to avoid or reduce the incidence of ADR to ensure medication safety.