目的 制備（S）-N-環(huán)氧丙基鄰苯二甲酰亞胺的單晶，并對(duì)其進(jìn)行結(jié)構(gòu)表征和均漿穩(wěn)定性研究。方法 通過溶劑揮發(fā)法和氣相擴(kuò)散法制備（S）-N-環(huán)氧丙基鄰苯二甲酰亞胺晶型。利用差示掃描量熱儀（DSC）、熱重分析儀（TGA），紅外光譜儀（IR），粉末X射線衍射儀（PXRD）和單晶X射線衍射儀（SXRD）分別對(duì)制備得到的晶體樣品進(jìn)行表征。結(jié)果 制備得到的（S）-N-環(huán)氧丙基鄰苯二甲酰亞胺晶體樣品，其DSC、TGA、IR和PXRD圖譜均一致，即晶型一致；DSC結(jié)合TGA分析結(jié)果顯示，（S）-N-環(huán)氧丙基鄰苯二甲酰亞胺熔點(diǎn)為100.56℃，分解溫度為128.2℃。單晶X射線衍射結(jié)果表明該晶胞屬于單斜晶系，P2₁空間群，結(jié)構(gòu)偏離因子R=0.04，分子式為C₁₁H₉NO₃，相對(duì)分子質(zhì)量為203.19，立體構(gòu)型與預(yù)測(cè)構(gòu)型一致。均漿穩(wěn)定性實(shí)驗(yàn)結(jié)果表明，不同極性溶劑中得到的晶體粉末X射線未發(fā)生變化，即晶型穩(wěn)定性良好。結(jié)論 實(shí)驗(yàn)確證了（S）-N-環(huán)氧丙基鄰苯二甲酰亞胺的立體結(jié)構(gòu)，且晶型穩(wěn)定性良好。

Objective To grow crystals of (S)-N-glycidyl phthalimide and investigate the corresponding structure and thermodynamic stability. Methods Evaporation and vapor diffusion methods were applied to grow crystals of (S)-N-glycidyl phthalimide. Different analysis methods including differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), infrared spectrometry (IR), powder X-ray diffraction (PXRD), and single X-ray diffraction (SXRD) were used to characterize the corresponding crystal structure. Results The DSC curves, TGA curves, IR spectra, and PXRD spectra of samples grown by the above methods were all consistent. Referring to the DSC and TGA results, the melting and decomposition temperatures were determined to be around 100.56℃ and 128.2℃, respectively. SXRD confirms the monoclinic lattice with space group P2₁ in (S)-N-glycidyl phthalimide crystal with a refinement value (R) of 0.04. Moreover, the chemical formula and relative molecular mass were C₁₁H₉NO₃ and 203.19, respectively. The measured crystal structure was in good agreement with the predicted one. Further, slurry experiments, which were performed in different polar solvents, confirmed the stability of the solid state of (S)-N-glycidyl phthalimide based on the PXRD determination. Conclusion Crystal structure of (S)-N-glycidyl phthalimide is characterized and the corresponding thermodynamic stability is investigated.

國家自然科學(xué)基金資助項(xiàng)目（21406071）