目的 探究二丁酰環(huán)磷腺苷鈣聯(lián)合尼可地爾治療急性ST段抬高型心肌梗死的臨床療效。方法 選取2016年7月-2017年7月開封市第二人民醫(yī)院心內(nèi)科及門診收治的急性ST段抬高型心肌梗死患者132例，隨機(jī)分為對(duì)照組和治療組，每組各66例。對(duì)照組患者口服尼可地爾片，1片/次，3次/d。治療組在對(duì)照組治療基礎(chǔ)上肌內(nèi)注射注射用二丁酰環(huán)磷腺苷鈣，20 mg/次，2次/d。兩組患者均連續(xù)用藥2周。觀察兩組的臨床療效，比較兩組治療前后左心室舒張末期內(nèi)徑（LVEDD）、左室射血分?jǐn)?shù)（LVEF）、左心室收縮末期內(nèi)徑（LVESD）、心肌肌鈣蛋白I（cTnI）、B型腦鈉肽（BNP）水平的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為83.33%、95.45%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者的LVEDD、LVESD、cTnI、BNP、心肌梗死面積均顯著降低，LVEF水平均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，LVEDD、LVESD、cTnI、BNP、心肌梗死面積顯著低于對(duì)照組，LVEF水平高于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 二丁酰環(huán)磷腺苷鈣聯(lián)合尼可地爾治療急性ST段抬高型心肌梗死具有較好的臨床療效，可顯著改善患者心功能指標(biāo)，改善心肌損傷水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of calcii dibutyry-ladenosini cyclophosphas combined with nicorandil in treatment of acute ST segment elevation myocardial infarction. Methods Patients (132 cases) with acute ST segment elevation myocardial infarction in Kaifeng Second People's Hospital from July 2016 to July 2017 were randomly divided into control (66 cases) and treatment (66 cases) groups. Patients in the control group were po administered with Nicorandil Tablets, 1 tablet/time, three times daily. Patients in the treatment group were im administered with Calcii Dibutyry-ladenosini Cyclophosphas for injection on the basis of the control group, 20 mg/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the changes of LVEDD, LVEF, LVESD, cTnI, and BNP in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 83.33% and 95.45%, and there were differences between two groups (P<0.05). After treatment, LVEDD, LVESD, cTnI, BNP and myocardial infarction area were significantly decreased in two groups, but LVEF was significantly increased, and there were differences in the same group (P<0.05). After treatment, LVEDD, LVESD, cTnI, BNP and myocardial infarction area in the treatment group were lower than those in the control groups, but LVEF was higher than that in the control group, and there were differences between two groups (P<0.05). Conclusions Calcii dibutyry-ladenosini cyclophosphas combined with nicorandil has significant clinical effect in treatment of acute ST segment elevation myocardial infarction, and can significantly improve the cardiac function indexes, and can improve the levels of myocardial injury, which has a certain clinical application value.