目的 探討應用大株紅景天注射液聯(lián)合丹參多酚酸鹽治療不穩(wěn)定型心絞痛的臨床效果。方法 選取2016年1月-2017年12月汕頭市潮陽區(qū)大峰醫(yī)院收治的不穩(wěn)定型心絞痛患者126例，隨機分成對照組（63例）與治療組（63例）。對照組靜脈滴注注射用丹參多酚酸鹽，200 mg加入5%葡萄糖注射液250 mL，1次/d。治療組在對照組的基礎上靜脈滴注大株紅景天注射液，10 mL加入5%葡萄糖液250 mL，1次/d。兩組均連續(xù)治療14 d。觀察兩組患者臨床療效，同時比較治療前后兩組患者低/高密度脂蛋白比值（LDL/HDL）比值、外周血中性粒細胞/淋巴細胞比值（NLR）、內(nèi)皮細胞微粒（EMPs）、血液流變學指標和血清學指標。結果 治療后，對照組和治療組臨床總有效率分別為73.0%和87.3%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組血清LDL/HDL比值和外周血NLR、EMPs值均顯著減少（P<0.01），且治療后治療組上述指標下降更明顯（P<0.01）。治療后兩組患者全血黏度（WBV）、纖維蛋白原（FIB）、紅細胞比容（Hct）值均顯著降低（P<0.01），且治療后治療組血流變指標明顯低于對照組（P<0.01）。治療后，兩組血清白細胞介素（IL）-2、IL-8、內(nèi)臟脂肪素（visfatin）和基質(zhì)金屬蛋白酶（MMP）-9濃度較治療前均明顯降低（P<0.05），且治療組上述血清學指標明顯低于對照組（P<0.05）。結論 大株紅景天注射液聯(lián)合丹參多酚酸鹽治療不穩(wěn)定型心絞痛可有效緩解患者癥狀，改善血液流變狀態(tài)，保護血管內(nèi)皮功能，增強斑塊穩(wěn)定性。

Objective To investigate the clinical effect of Sofren Injection combined with salvianolate in treatment of unstable angina pectoris. Methods Patients (126 cases) with unstable angina pectoris in Dafeng Hospital of Chaoyang District in Shantou from January 2016 to December 2017 were randomly divided into control (63 cases) and treatment (63 cases) groups. Patients in the control group were iv administered with Salvianolate for injection, 200 mg added into 5% glucose injection 250 mL, once daily. Patients in the treatment group were iv administered with Sofren Injection on the basis of the control group, 10 mL added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and LDL/HDL, NLR, EMPs, the hemorheological and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 73.0% and 87.3% respectively, and there were differences between two groups (P<0.05). After treatment, the LDL/HDL, NLR and EMPs in two groups were significantly decreased (P<0.01), and these indexes in the treatment group after treatment were significantly lower than those in the control group (P<0.01). After treatment, the WBV, FIB and Hct in two groups were significantly decreased (P<0.01), and the hemorheological indexes in the treatment group after treatment were significantly lower than those in the control group (P<0.01). After treatment, the IL-2, IL-8, visfatin and MMP-9 levels in two groups were significantly decreased (P<0.05), and the serological indexes in the treatment group after treatment were significantly lower than those in the control group (P<0.05). Conclusion Sofren Injection combined with salvianolate in treatment of unstable angina pectoris can effectively alleviate the symptoms, improve hemorrheology state, protect the vascular endothelial function and strengthen the plaque stability.