目的 探討安腦丸聯(lián)合阿立哌唑治療精神分裂癥的臨床療效。方法 選取2015年4月-2017年4月在河南省洛陽榮康醫(yī)院進行診治的精神分裂癥患者92例，隨機分為對照組（46例）和治療組（46例）。對照組口服阿立哌唑片，第1周劑量5 mg/d，第2周10 mg/d，之后根據(jù)療效和耐受情況增至15 mg/d維持治療，1次/d；治療組在對照組的基礎(chǔ)上口服安腦丸，2丸/次，2次/d。兩組均治療6周。觀察兩組患者臨床療效，比較治療前后兩組患者PANSS、GQOLI-74和PSP評分以及血清學(xué)指標。結(jié)果 治療后，對照組和治療組的臨床有效率分別為80.43%和95.65%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者PANSS評分顯著降低，GQOLI-74和PSP評分顯著升高，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05），且治療組上述評分明顯優(yōu)于對照組（P<0.05）。治療后，兩組患者神經(jīng)元特異性烯醇化酶（NSE）、S100β蛋白、髓鞘堿性蛋白（MBP）水平均顯著降低，膠質(zhì)源性神經(jīng)營養(yǎng)因子（GDNF）水平顯著升高，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05），且治療組上述血清學(xué)指標明顯優(yōu)于對照組（P<0.05）。結(jié)論 安腦丸聯(lián)合阿立哌唑治療精神分裂癥可有效改善患者陽性和陰性癥狀，改善機體NSE、S100B蛋白、MBP、GDNF水平，具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical efficacy of Annao Pills combined with aripiprazole in treatment of schizophrenia. Methods Patients (92 cases) with schizophrenia in Henan Province Had Luoyang Hospital from April 2015 to April 2017 were randomly divided into control (46 cases) and treatment (46 cases) groups. Patients in the control group were po administered with Aripiprazole Tablets, 5 mg/d for the 1st week, 10 mg/d for the 2nd week, then increased to 15 mg/d for maintaining treatment according to the efficacy and tolerance, once daily. Patients in the treatment group were po administered with Annao Pills on the basis of the control group, 2 pills/time, twice daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacy was evaluated, and the PANSS, GQOLI-74, and PSP scores, the serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.43% and 95.65%, respectively, and there were differences between two groups (P<0.05). After treatment, the PANSS scores in two groups were significantly decreased, but GQOLI-74 and PSP scores were significantly increased, and the difference was statistically significant in the same group (P<0.05), and these scores in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the NSE, S100β and MBP levels in two groups were significantly decreased, but GDNF levels were significantly increased, and the difference was statistically significant in the same group (P<0.05), and the serological indexes in the treatment group after treatment were significantly better than those in the control group (P<0.05). Conclusion Annao Pills combined with aripiprazole in treatment of schizophrenia can effectively improve the positive and negative symptoms, and improve the NSE,S100β protein, MBP and GDNF levels, which has a certain clinical application value.