目的 探討小兒雙金清熱口服液聯(lián)合磷酸奧司他韋膠囊治療甲型流行性感冒（流感）的臨床療效。方法 選取2016年2月-2017年2月在延安市人民醫(yī)院兒科和門(mén)診進(jìn)行治療的甲型流感患者113例作為研究對(duì)象，在隨機(jī)分組的原則下將患者隨機(jī)分為對(duì)照組（56例）和治療組（57例）。對(duì)照組患者口服磷酸奧司他韋膠囊，75 mg/次，2次/d；治療組患者在對(duì)照組治療的基礎(chǔ)上口服小兒雙金清熱口服液，10 mL/次，3次/d。兩組患者均連續(xù)治療5 d。觀察兩組患者的臨床療效，同時(shí)比較治療前后兩組患者體溫恢復(fù)時(shí)間、癥狀消失時(shí)間、病毒核酸陽(yáng)性持續(xù)時(shí)間、細(xì)胞免疫指標(biāo)和體液免疫指標(biāo)水平。結(jié)果 治療后，對(duì)照組、治療組總有效率分別為83.93%、96.49%，兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組體溫恢復(fù)時(shí)間、癥狀消失時(shí)間和病毒核酸陽(yáng)性持續(xù)時(shí)間均顯著短于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清CD8⁺水平顯著降低，CD4⁺、IgA、IgM水平均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組細(xì)胞免疫和體液免疫指標(biāo)明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 小兒雙金清熱口服液聯(lián)合奧司他韋膠囊治療甲型流感具有較好的臨床療效，改善臨床癥狀，提高免疫力，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effects of Xiao'er Shuangjin Qingre Oral Liquid combined with Oseltamivir Phosphate Capsules in treatment of influenza. Methods Patients (113 cases) with influenza in Yan'an People's Hospital from February 2016 to February 2017 were randomly divided into control (56 cases) and treatment (57 cases) groups. Patients in the control group were po administered with Oseltamivir Phosphate Capsules, 75 mg/time, twice daily. Patients in the treatment group were po administered with Xiao'er Shuangjin Qingre Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 5 days. After treatment, the clinical efficacy was evaluated, and the recovery time of body temperature, symptoms disappeared time, viral nucleic acid positive duration, and levels of cellular immune indexes and humoral immune indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.93% and 96.49%, respectively, and there were differences between two groups (P<0.05). After treatment, the recovery time of body temperature, symptoms disappeared time and duration of virus nucleic acid positive in the treatment group were significantly shorter than those in the control groups, and there was difference between two groups (P<0.05). After treatment, the CD8⁺ levels in two groups were significantly decreased, but CD4⁺, IgA, and IgM levels were significantly increased, and the difference was statistically significant in the same group (P<0.05). And levels of cellular immune indexes and humoral immune indexes in the treatment group after treatment were significantly better than those in the control group (P<0.05). Conclusion Xiao'er Shuangjin Qingre Oral Liquid combined with Oseltamivir Phosphate Capsules has obvious curative effect in treatment of influenza, can improve the clinical symptoms and the immunity, which has a certain clinical application value.