目的 探討少腹逐瘀膠囊聯(lián)合氨曲南治療慢性盆腔炎的臨床療效。方法 選取2016年10月-2017年10月在瓊中黎族苗族自治縣中醫(yī)院進(jìn)行診治的146例慢性盆腔炎患者，隨機(jī)分為對照組和治療組，每組各73例。對照組靜脈滴注注射用氨曲南，2.0 g與0.9%氯化鈉注射液配伍，2次/d。治療組在對照組治療基礎(chǔ)上口服少腹逐瘀膠囊，3粒/次，3次/d。兩組均連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組臨床癥狀消失時間、盆腔炎性包塊直徑、盆腔積液、血清細(xì)胞因子的情況。結(jié)果 治療后，對照組和治療組的總有效率分別為80.82%、97.26%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組下腹腰骶疼痛消失時間、白帶增多消失時間、退熱時間、盆腔腫塊消失時間均顯著短于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者盆腔炎性包塊直徑、盆腔積液量、血清白細(xì)胞介素-1β（IL-1β）、腫瘤壞死因子-α（TNF-α）水平均顯著降低，但轉(zhuǎn)化生長因子-β1（TGF-β1）、白細(xì)胞介素-4（IL-4）水平均顯著增高，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；治療后，治療組盆腔炎性包塊直徑、盆腔積液量、IL-1β、TNF-α水平顯著低于對照組，TGF-β1、IL-4水平高于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 少腹逐瘀膠囊聯(lián)合氨曲南治療慢性盆腔炎具有較好的臨床療效，可有效改善患者臨床癥狀，降低機(jī)體炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical effect of Shaofu Zhuyu Capsules combined with aztreonam in treatment of chronic pelvic inflammation. Methods Patients (146 cases) with chronic pelvic inflammation in Qiongzhong Li Miao Autonomous County Hospital from October 2016 to October 2017 were randomly divided into control (73 cases) and treatment (73 cases) groups. Patients in the control group were iv administered with Aztreonam for Injection, 2.0 g added into normal saline, twice daily. Patients in the treatment group were po administered with Shaofu Zhuyu Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom disappearance time, pelvic inflammatory mass diameter, pelvic effusion, and serum cytokines were compared between the two groups. Results After the treatment, the clinical efficacy in the control group were 80.82% and 97.26%, and there were differences between two groups (P<0.05). After treatment, the pain disappeared time of the lower lumbosacral region, disappeared time of the leucorrhea increased, defervescence time, and the disappeared time of pelvic mass were significantly shorter than those in the control group, and there were differences between two groups (P<0.05). After treatment, the pelvic inflammatory mass diameter, pelvic effusion volume, serum IL-1β, TNF-α were significantly decreased, but TGF-β1 and IL-4 were significantly increased, and there were differences in the same group (P<0.05). After treatment, the pelvic inflammatory mass diameter, pelvic effusion volume, serum IL-1β, TNF-α in the treatment group were lower than those in the control, but TGF-β1 and IL-4 were higher than those in the control group, and there were differences between two groups (P<0.05). Conclusion Shaofu Zhuyu Capsule combined with aztreonam has significant clinical effect in treatment of chronic pelvic inflammation, and can effectively improve clinical symptoms, and reduce the inflammatory reaction, which has a certain clinical application value.